The bioactive sphingolipid metabolites ceramide and sphingosine-1-phosphate (S1P) are a
recent addition to the lipids accumulated in obesity and have emerged as important …

The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

In obesity and dyslipidemia, the oversupply of fat to tissues not suited for lipid storage
induces cellular dysfunction that underlies diabetes and cardiovascular disease (ie …

Much has been made about JLW Thudichum's colorful, and one could say clairvoyant,
naming of sphingosine “in commemoration of the many enigmas which it presented to the …

Insulin resistance condition is associated to the development of several syndromes, such as
obesity, type 2 diabetes mellitus and metabolic syndrome. Although the factors linking …

Non-alcoholic fatty liver disease (NAFLD) has emerged as one of the main causes of chronic
liver disease worldwide. NAFLD comprises a group of conditions characterized by the …

Pancreatic β cell dysfunction is pathognomonic of type 2 diabetes mellitus (T2DM) and is
driven by environmental and genetic factors. β cell responses to glucose and to incretins …

Diabetic cardiomyopathy (DbCM), which consists of cardiac hypertrophy and failure in the
absence of traditional risk factors, is a major contributor to increased heart failure risk in type …

Lipidomics is a rapidly growing field with numerous examples showing the importance of
lipid molecules throughout biology. It has also shed light onto the vast and complex …

Nutrient oversupply associated with a high fat diet (HFD) significantly alters cellular
metabolism, and specifically including sphingolipid metabolism. Sphingolipids are emerging …