Overview of recent strategic advances in medicinal chemistry

G Wu, T Zhao, D Kang, J Zhang, Y Song… - Journal of medicinal …, 2019 - ACS Publications
Introducing novel strategies, concepts, and technologies that speed up drug discovery and
the drug development cycle is of great importance both in the highly competitive …

Diversity of AMPA receptor ligands: Chemotypes, binding modes, mechanisms of action, and therapeutic effects

EA Golubeva, MI Lavrov, EV Radchenko, VA Palyulin - Biomolecules, 2022 - mdpi.com
L-Glutamic acid is the main excitatory neurotransmitter in the central nervous system (CNS).
Its associated receptors localized on neuronal and non-neuronal cells mediate rapid …

Photoinduced Rapid Multicomponent Cascade Reaction of Aryldiazonium Salts with Unactivated Alkenes and TMSN3

J Shen, J Xu, L He, Y Ouyang, L Huang, W Li… - Organic …, 2021 - ACS Publications
The first example of a photoinduced rapid multicomponent cascade reaction of
aryldiazonium salts with unactivated alkenes and trimethylsilyl azide (TMSN3) under oxidant …

The chemistry and biology of guanidine secondary metabolites

RGS Berlinck, DI Bernardi, T Fill… - Natural Product …, 2021 - pubs.rsc.org
Covering: 2017–2019 Guanidine natural products isolated from microorganisms, marine
invertebrates and terrestrial plants, amphibians and spiders, represented by non-ribosomal …

Fukuyama reduction, Fukuyama coupling and Fukuyama–Mitsunobu alkylation: recent developments and synthetic applications

S Sikandar, AF Zahoor, S Naheed, B Parveen, KG Ali… - Molecular Diversity, 2022 - Springer
Fukuyama reaction for the synthesis of multifunctional aldehydes, secondary amines and
ketones has gained considerable importance in synthetic organic chemistry because of mild …

Modular synthesis of alkylarylazo compounds via iron (III)-catalyzed olefin hydroamination

Y Zhang, C Huang, X Lin, Q Hu, B Hu, Y Zhou… - Organic letters, 2019 - ACS Publications
A novel Fe-catalyzed olefin hydroamination with aryldiazo sulfones for accessing
alkylarylazo compounds has been successfully developed. Aryldiazo sulfones are used as …

Hypervalent iodine (III)-promoted rapid cascade reaction for the synthesis of unsymmetric azo compounds

J Shen, J Xu, Q Zhu, P Zhang - Organic & Biomolecular Chemistry, 2021 - pubs.rsc.org
A rapid three-component cascade reaction for the synthesis of unsymmetric azo compounds
via a radical activation strategy has been reported. Various aryldiazonium salts and …

Trichloroisocyanuric Acid Mediated Oxidative Dehydrogenation of Hydrazines: A Practical Chemical Oxidation To Access Azo Compounds

Y Su, X Liu, J Yu, G Cao, R Zhang, Y Zhao… - …, 2020 - thieme-connect.com
A highly efficient, metal-free, chemical oxidation of hydrazines has been implemented using
environmentally friendly TCCA as oxidant. This benign protocol provides straightforward …

Copper-catalyzed direct carbodiazenylation of cycloalkanes with aryldiazonium salts under redox neutral conditions

F Zhu, J Luo, XF Wu - Journal of Catalysis, 2023 - Elsevier
Diazenes are of particular importance in organic synthesis and routinely utilized as dyes,
photoswitches, indicators, radical reaction initiators, food additives, and pharmaceuticals. In …

Ligands of the AMPA-subtype glutamate receptors: Mechanisms of action and novel chemotypes

EV Radchenko, AS Tarakanova… - Biomeditsinskaya …, 2021 - pbmc.ibmc.msk.ru
Ionotropic glutamate receptors of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
(AMPA) subtype play a key role in synaptic plasticity representing one of the mechanisms for …