Cerebrovascular disease in ageing and Alzheimer's disease

S Love, JS Miners - Acta neuropathologica, 2016 - Springer
Cerebrovascular disease (CVD) and Alzheimer's disease (AD) have more in common than
their association with ageing. They share risk factors and overlap neuropathologically. Most …

Neprilysin inhibitors and risk of Alzheimer's disease: A future perspective

NH Ali, HM Al‐Kuraishy, AI Al‐Gareeb… - Journal of cellular …, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease with multifaceted
neuropathological disorders. AD is characterized by intracellular accumulation of …

Neuroprotective effects of pomegranate peel extract after chronic infusion with amyloid-β peptide in mice

MC Morzelle, JM Salgado, M Telles, D Mourelle… - PloS one, 2016 - journals.plos.org
Alzheimer's disease is a chronic and degenerative condition that had no treatment until
recently. The current therapeutic strategies reduce progression of the disease but are …

Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms

A Nokkari, H Abou-El-Hassan, Y Mechref… - Progress in …, 2018 - Elsevier
Neurological disorders represent major health concerns in terms of comorbidity and
mortality worldwide. Despite a tremendous increase in our understanding of the …

Angiotensin receptor blockers and cognition: a scoping review

Z Zhou, SG Orchard, MR Nelson, MA Fravel… - Current hypertension …, 2024 - Springer
Abstract Purpose of Review To provide an overview of the association between angiotensin
II receptor blocker (ARB) use and cognitive outcomes. Recent Findings ARBs have …

[HTML][HTML] Increased plasma bradykinin level is associated with cognitive impairment in Alzheimer's patients

PK Singh, ZL Chen, D Ghosh, S Strickland… - Neurobiology of …, 2020 - Elsevier
Alzheimer's disease (AD) is characterized by the presence of proteinaceous brain deposits,
brain atrophy, vascular dysfunction, and chronic inflammation. Along with cerebral …

Investigation of Potential Drug Targets Involved in Inflammation Contributing to Alzheimer's Disease Progression

C Sharo, T Zhai, Z Huang - Pharmaceuticals, 2024 - mdpi.com
Alzheimer's disease has become a major public health issue. While extensive research has
been conducted in the last few decades, few drugs have been approved by the FDA to treat …

Neuropeptides in Alzheimer's disease: an update

C Petrella, MG Di Certo, C Barbato… - Current Alzheimer …, 2019 - ingentaconnect.com
Neuropeptides are small proteins broadly expressed throughout the central nervous system,
which act as neurotransmitters, neuromodulators and neuroregulators. Growing evidence …

Synaptic plasticity modulation by circulating peptides and metaplasticity: involvement in Alzheimer's disease

S Peineau, K Rabiant, O Pierrefiche, B Potier - Pharmacological Research, 2018 - Elsevier
Synaptic plasticity is a cellular process involved in learning and memory whose alteration in
its two main forms (Long Term Depression (LTD) and Long Term Potentiation (LTP)), is …

Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer's disease mice

B Lacoste, XK Tong, K Lahjouji, R Couture… - Journal of …, 2013 - Springer
Background Recent evidence suggests that the inducible kinin B 1 receptor (B 1 R)
contributes to pathogenic neuroinflammation induced by amyloid-beta (Aβ) peptide. The …