Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

S Alberti, AA Hyman - Nature reviews Molecular cell biology, 2021 - nature.com
Biomolecular condensates are membraneless intracellular assemblies that often form via
liquid− liquid phase separation and have the ability to concentrate biopolymers. Research …

Aging hallmarks and the role of oxidative stress

E Maldonado, S Morales-Pison, F Urbina, A Solari - Antioxidants, 2023 - mdpi.com
Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity

A de Morree, TA Rando - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

The proteostasis network and its decline in ageing

MS Hipp, P Kasturi, FU Hartl - Nature reviews Molecular cell biology, 2019 - nature.com
Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …

Formation and integration of new neurons in the adult hippocampus

A Denoth-Lippuner, S Jessberger - Nature Reviews Neuroscience, 2021 - nature.com
Neural stem cells (NSCs) generate new neurons throughout life in the mammalian brain.
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …

Adult hippocampal neurogenesis in aging and Alzheimer's disease

KR Babcock, JS Page, JR Fallon, AE Webb - Stem cell reports, 2021 - cell.com
Cognitive deficits associated with Alzheimer's disease (AD) severely impact daily life for the
millions of affected individuals. Progressive memory impairment in AD patients is associated …

Aging and rejuvenation of neural stem cells and their niches

PN Negredo, RW Yeo, A Brunet - Cell stem cell, 2020 - cell.com
Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …

Quiescence of adult mammalian neural stem cells: a highly regulated rest

N Urbán, IM Blomfield, F Guillemot - Neuron, 2019 - cell.com
Neural stem cells in the adult mammalian brain are the source of new neurons that
contribute to complex sensory and cognitive functions. Most adult neural stem cells are …

Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons

N Habib, Y Li, M Heidenreich, L Swiech… - Science, 2016 - science.org
Single-cell RNA sequencing (RNA-Seq) provides rich information about cell types and
states. However, it is difficult to capture rare dynamic processes, such as adult …

Live imaging of neurogenesis in the adult mouse hippocampus

GA Pilz, S Bottes, M Betizeau, DJ Jörg, S Carta, S April… - Science, 2018 - science.org
Neural stem and progenitor cells (NSPCs) generate neurons throughout life in the
mammalian hippocampus. We used chronic in vivo imaging and followed genetically …