Patient-derived xenograft (PDX) models are increasingly being used in oncology drug
development because they offer greater predictive value than traditional cell line models …

The Wnt signaling is of paramount pathophysiological importance. Despite showing
promising anticancer activities in pre-clinical studies, current Wnt pathway inhibitors face …

Wnt signaling is overactivated in triple-negative breast cancer (TNBC) and several other
cancers, and its suppression emerges as an effective anticancer treatment. However, no …

Many solid cancers have an expanded CD44+/hi/CD24−/low cancer stem cell (CSC)
population, which are relatively chemoresistant and drive recurrence and metastasis …

Gastric cancer (GC) has high mortality owing to its aggressive nature. Tumor angiogenesis
plays an essential role in the growth, invasion, and metastatic spread of GC. The aim of this …

Over the last decades, major technological advancements have led to a better
understanding of the molecular drivers of human malignancies. Nonetheless, this progress …

The growing body of evidence suggests that breast cancer (BC) who achieve pathological
complete response (pCR) after neoadjuvant chemotherapy (NAC) may experience a more …

Transforming growth factor β (TGFβ) is a key regulator of epithelial-to-mesenchymal
transition (EMT) during embryogenesis and in tumors. The effect of TGFβ, on ΕΜΤ, is …

Developing anticancer drugs from preclinical to clinical takes approximately a decade in a
cutting-edge biomedical lab and still 97% of most fail at clinical trials. Cell line usage is …

WNT signaling plays paramount roles in organism development, physiology, and disease,
representing a highly attractive target for drug development. However, no WNT-modulating …