NKG2D is an activating receptor expressed on the surface of natural killer (NK) cells, CD8+
T cells, and subsets of CD4+ T cells, invariant NKT cells (iNKT), and γδ T cells. In humans …

The coordinated activities of innate and adaptive immunity are critical for effective protection
against viruses. To counter this, some viruses have evolved sophisticated strategies to …

The organelles within a eukaryotic host are manipulated by viruses to support successful
virus replication and spread of infection, yet the global impact of viral infection on host …

In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV),
we reflect on the merits and limitations of the viral strains currently being used to develop …

Human cytomegalovirus is a widespread pathogen of major medical importance. It causes
significant morbidity and mortality in immunocompromised individuals, and congenital …

Major mechanisms for the recognition of pathogens by immune cells have evolved to
employ classical and non-classical major histocompatibility complex class I (MHC I) …

Human cytomegalovirus (HCMV) is an important pathogen with multiple immune evasion
strategies, including virally facilitated degradation of host antiviral restriction factors. Here …

Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating> 900
human proteins during viral replication and degrading≥ 133 proteins shortly after infection …

Butyrophilin molecules (commonly contracted to BTN), collectively take their name from the
eponymous protein in cow's milk. They are considered to be members of the B7 family of …

Natural killer (NK) cells are cytotoxic effector cells that target and lyse virally infected cells;
many viruses therefore encode mechanisms to escape such NK cell killing. Here, we …