The immune response to an allograft activates lymphocytes with the capacity to cause
rejection. Activation of CD4+ CD25+ Foxp3+ T regulatory cells (Treg) can down-regulate …

There is an increase in the older incident end-stage renal disease population that is
associated with an increasing prevalence of end-stage renal disease in the United States …

Several transplant patients maintain stable kidney graft function in the absence of
immunosuppression. Here we compared the characteristics of their peripheral B cells to that …

The role of Foxp3+ regulatory T cells (Tregs) in operational tolerance remains elusive, as
initial results revealed an increased frequency of this subset in tolerant patients but no …

In a cross-sectional study, we assessed effects of calcineurin inhibitor (CNI) or rapamycin on
T-regulatory (Treg) cells from children with stable liver (n= 53) or kidney (n= 9) allografts …

It is well-established that significant ischemia-reperfusion injury during kidney
transplantation results in increased incidence of long-term fibrosis and rejection. To test for a …

Allograft tolerance, in which a graft is accepted without long-term immunosuppression, could
overcome numerous obstacles in transplantation. Human allograft tolerance has been …

Multiple sclerosis (MS) is a chronic inflammatory disease that results in demyelination in the
central nervous system, and a defect in the regulatory function of CD4+ CD25high T cells …

Transplanted individuals in operational tolerance (OT) maintain long-term stable graft
function after completely stopping immunosuppression. Understanding the mechanisms …

Healthy liver, intestine, lung, and skin harbor resident lymphocytes with conventional and
unconventional phenotypes. Lymphocytes also have been detected in healthy mice kidneys; …