Microglia-mediated neuroinflammation in neurodegenerative diseases

CS Subhramanyam, C Wang, Q Hu… - Seminars in cell & …, 2019 - Elsevier
Microglia, being the resident immune cells of the central nervous system, play an important
role in maintaining tissue homeostasis and contributes towards brain development under …

[HTML][HTML] The biological pathways of Alzheimer disease: A review

M Calabrò, C Rinaldi, G Santoro, C Crisafulli - AIMS neuroscience, 2021 - ncbi.nlm.nih.gov
Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older
people, which severely impairs patients' quality of life. In the recent years, the number of …

[HTML][HTML] Forsythoside a mitigates alzheimer's-like pathology by inhibiting ferroptosis-mediated neuroinflammation via Nrf2/GPX4 axis activation

C Wang, S Chen, H Guo, H Jiang, H Liu… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Ferroptosis and neuroinflammation play crucial roles in Alzheimer's disease (AD)
pathophysiology. Forsythoside A (FA), the main constituent of Forsythia suspensa (Thunb.) …

Modifiable risk factors for Alzheimer's disease

GA Edwards III, N Gamez, G Escobedo Jr… - Frontiers in aging …, 2019 - frontiersin.org
Since first described in the early 1900s, Alzheimer's disease (AD) has risen exponentially in
prevalence and concern. Research still drives to understand the etiology and pathogenesis …

Diagnostic contribution and therapeutic perspectives of transcranial magnetic stimulation in dementia

V Di Lazzaro, R Bella, A Benussi, M Bologna… - Clinical …, 2021 - Elsevier
Transcranial magnetic stimulation (TMS) is a powerful tool to probe in vivo brain circuits, as it
allows to assess several cortical properties such as excitability, plasticity and connectivity in …

Dopamine and dopamine receptors in Alzheimer's disease: a systematic review and network meta-analysis

X Pan, AC Kaminga, SW Wen, X Wu… - Frontiers in aging …, 2019 - frontiersin.org
Background: The dopaminergic system has been associated with the progression of
Alzheimer's disease. But previous studies found inconsistent results regarding the …

Brain and peripheral atypical inflammatory mediators potentiate neuroinflammation and neurodegeneration

D Kempuraj, R Thangavel, GP Selvakumar… - Frontiers in cellular …, 2017 - frontiersin.org
Neuroinflammatory response is primarily a protective mechanism in the brain. However,
excessive and chronic inflammatory responses can lead to deleterious effects involving …

The biology and pathobiology of glutamatergic, cholinergic, and dopaminergic signaling in the aging brain

A Gasiorowska, M Wydrych, P Drapich… - Frontiers in aging …, 2021 - frontiersin.org
The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …

Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease

P Krashia, A Cordella, A Nobili, L La Barbera… - Nature …, 2019 - nature.com
Neuroinflammation is one of the hallmarks of Parkinson's disease (PD) and may contribute
to midbrain dopamine (DA) neuron degeneration. Recent studies link chronic inflammation …

The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases

E Possemato, L La Barbera, A Nobili, P Krashia… - Ageing research …, 2023 - Elsevier
Abstract In the Central Nervous System (CNS), neuroinflammation orchestrated by microglia
and astrocytes is an innate immune response to counteract stressful and dangerous insults …