Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

Oxidation chemistry using enzymes is approaching maturity and practical applicability in
organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists …

Selective functionalization of aliphatic C–H bonds, ubiquitous in molecular structures, could
allow ready access to diverse chemical products. While enzymatic oxygenation of C–H …

As the enzyme toolbox for biocatalysis has expanded, so has the potential for the
construction of powerful enzymatic cascades for efficient and selective synthesis of target …

Chiral amines are pivotal building blocks for the pharmaceutical industry. Asymmetric
reductive amination is one of the most efficient and atom economic methodologies for the …

Cytochromes P450 (P450 or CYP) are heme-containing enzymes that catalyze the
introduction of one atom of molecular oxygen into nonactivated C–H bonds, often in a regio …

The synthesis of secondary and tertiary amines through the reductive amination of carbonyl
compounds is one of the most significant reactions in synthetic chemistry. Asymmetric …

Alcohol dehydrogenases (ADHs) have become important catalysts for stereoselective
oxidation and reduction reactions of alcohols, aldehydes and ketones. The aim of this …

Cytochrome P450s (CYPs) are heme-thiolated enzymes that catalyze the oxidation of C
single bond H bonds in a regio and stereoselective manner. Activation of the non-activated …

Spirocyclobutane derivatives have gained significant attention in drug discovery programs
due to their broad spectrum of biological activities and clinical applications. Ring-strain in …