Discovering effective agents to slow or stop neurodegeneration is a challenging task. Over
decades, only a few drugs were approved by Food and Drug Administration (FDA) and most …

Phthalides, mainly isolated from two genera: Ligusticum and Angelica of the Apiceae (syn
Umbelliferae) family, are thought to be a potent natural compound with many therapeutic …

Abstract L-3-n-butylphthalide (NBP), a compound found in Apium graveolens Linn seed
extracts, has a therapeutic effect on acute ischemic stroke. The pathological inflammatory …

Introduction Dencichine, one of the non-protein amino acids present in the roots of Panax
notoginseng, has been found to shorten bleeding time of mice and increase the number of …

For the first time, a series of highly potent natural product inspired substituted (Z)-3-
benzylideneisobenzofuran-1 (3H)-ones 28a-t, embraced with electron-withdrawing groups …

Background: Stroke can cause physical and mental problems. This study examined how the
sequential therapy of N-butylphthalide (NBP) could effectively improve physical movement …

The West Nile Virus (WNV) NS2B-NS3 protease is an attractive target for the development of
therapeutics against this arboviral pathogen. In the present investigation, the screening of a …

目的观察采用重组组织型纤溶酶原激活物(rt-PA) 溶栓前及早给予丁苯酞注射液对超早期急性脑
梗死(ACI) 患者预后的影响. 方法采用前瞻性研究方法. 选择2014 年9 月至2016 年3 …

A series of thirteen C-3 functionalized isobenzofuran-1 (3H)-ones (phtalides) was
synthesized via condensation, aromatization, and acetylation reactions. NMR (one and two …

Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp. AL031
isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone …