CAR T cells beyond cancer: hope for immunomodulatory therapy of infectious diseases
M Seif, H Einsele, J Löffler - Frontiers in immunology, 2019 - frontiersin.org
Infectious diseases are still a significant cause of morbidity and mortality worldwide. Despite
the progress in drug development, the occurrence of microbial resistance is still a significant …
the progress in drug development, the occurrence of microbial resistance is still a significant …
Strategies to eradicate HIV from infected patients: elimination of latent provirus reservoirs
I Sadowski, FB Hashemi - Cellular and Molecular Life Sciences, 2019 - Springer
Abstract 35 years since identification of HIV as the causative agent of AIDS, and 35 million
deaths associated with this disease, significant effort is now directed towards the …
deaths associated with this disease, significant effort is now directed towards the …
[PDF][PDF] ART and Platelet Dynamics: Assessing Implications for HIV Patient Care
Antiretroviral therapy (ART) has drastically improved the prognosis of HIV infection, yet its
effects on platelet dynamics raise concerns regarding hematological complications …
effects on platelet dynamics raise concerns regarding hematological complications …
[PDF][PDF] Antacid Use in HIV Patients: Implications for Drug Absorption, Metabolism, and Adverse Effects
Antacid use is prevalent among HIV patients due to gastrointestinal symptoms and the side
effects of antiretroviral therapy (ART). This review examines the implications of antacid use …
effects of antiretroviral therapy (ART). This review examines the implications of antacid use …
[HTML][HTML] Piecewise differentiation of the fractional order CAR-T cells-SARS-2 virus model
The pandemic caused by the SARS-CoV2 virus has prompted research into new therapeutic
solutions that can be used to treat the CoVid-19 syndrome. As part of this research …
solutions that can be used to treat the CoVid-19 syndrome. As part of this research …
Targeted chromatinization and repression of HIV-1 provirus transcription with repurposed CRISPR/Cas9
The major barrier to HIV-1 cure is the persistence of latent provirus, which is not eradicated
by antiretroviral therapy. The “shock and kill” approach entails stimulating viral production …
by antiretroviral therapy. The “shock and kill” approach entails stimulating viral production …
HIV cure strategies: which ones are appropriate for Africa?
Although combination antiretroviral therapy (ART) has reduced mortality and improved
lifespan for people living with HIV, it does not provide a cure. Patients must be on ART for …
lifespan for people living with HIV, it does not provide a cure. Patients must be on ART for …
Could gene therapy cure HIV?
Abstract The Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome
(AIDS) continues to be a major global public health issue, having claimed almost 33 million …
(AIDS) continues to be a major global public health issue, having claimed almost 33 million …
Interferons and beyond: Induction of antiretroviral restriction factors
D Hotter, F Kirchhoff - Journal of leukocyte biology, 2018 - academic.oup.com
Antiviral restriction factors are structurally and functionally diverse cellular proteins that play
a key role in the first line of defense against viral pathogens. Although many cell types …
a key role in the first line of defense against viral pathogens. Although many cell types …
What do we (not) know about global views of human gene editing? Insights and blind spots in the CRISPR era
As research on human applications of CRISPR advances, researchers, advisory bodies, and
other stakeholder organizations continue calling for global public discourses and …
other stakeholder organizations continue calling for global public discourses and …