The skeleton is diverse in its functions, which include mechanical support, movement, blood
cell production, mineral storage and endocrine regulation. This multifaceted role is achieved …

Background Late in the nineteenth century, it was theorized that a circulating product
produced by the parathyroid glands could negatively impact skeletal homeostasis. A century …

Aged bone marrow mesenchymal stem cells (BMSCs) exhibit aberrant self-renewal and
lineage specification, which contribute to imbalanced bone-fat and progressive bone loss. In …

Background As common progenitor cells of osteoblasts and adipocytes, bone marrow
mesenchymal (stromal) stem cells (BMSCs) play key roles in bone homeostasis, tissue …

The fate of hematopoietic stem and progenitor cells (HSPC) is tightly regulated by their bone
marrow (BM) microenvironment (ME). BM transplantation (BMT) frequently requires …

Bone development and bone remodelling during adult life are highly anabolic processes
requiring an adequate supply of oxygen and nutrients. Bone-forming osteoblasts and bone …

Abstract N 6-methyladenosine (m 6 A), a novel epitranscriptomic RNA modification, plays
crucial roles in a variety of biological processes and diseases. Recently, there are growing …

Mesenchymal stromal cells (MSCs) are essential elements of the bone marrow (BM)
microenvironment, which have been widely implicated in pathways that contribute to …

Background Controlling the adipo-osteogenic lineage commitment of bone marrow
mesenchymal stem cell (BMSC) in favor of osteogenesis is considered a promising …

Osteoporosis is a common endocrinologic disorder characterized as a chronic bone loss
condition. Sexual dimorphism is ubiquitous in the incidence of osteoporosis with post …