Internal modifications in the CENP-A nucleosome modulate centromeric dynamics

M Bui, M Pitman, A Nuccio, S Roque… - Epigenetics & …, 2017 - Springer
Background Posttranslational modifications of core histones are correlated with changes in
transcriptional status, chromatin fiber folding, and nucleosome dynamics. However, within …

Native and tagged CENP-A histones are functionally inequivalent

M Bui, S Baek, RS Bentahar, DP Melters… - Epigenetics & Chromatin, 2024 - Springer
Background Over the past several decades, the use of biochemical and fluorescent tags has
elucidated mechanistic and cytological processes that would otherwise be impossible. The …

Epigenetics Tune Chromatin Mechanics, a Computational Approach

M Pitman - 2021 - search.proquest.com
The base unit of DNA packaging in eukaryotes, the nucleosome, is adaptively modified for
epigenetic control. Given the vast chemical space of chromatin and complexity of signaling …