Cell migration is crucial for physiological and pathological processes such as
morphogenesis, wound repair, immune response and cancer invasion/metastasis. There are …

Life science research is advancing rapidly in the 21st century. Many innovative technologies
and methodologies are being applied in various fields of the life sciences to reveal how …

Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era.
We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data …

Actin filaments generate mechanical forces that drive membrane movements during
trafficking, endocytosis and cell migration. Reciprocally, adaptations of actin networks to …

The tightly coordinated, spatiotemporal control of actin filament remodeling provides the
basis of fundamental cellular processes, such as cell migration and adhesion. Specific …

Motile cells inside living tissues often encounter junctions, where their path branches into
several alternative directions of migration. We present a theoretical model of cellular …

Abstract Proteins of the Wiskott-Aldrich syndrome protein (WASP) family play a central role
in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic …

Ribosome profiling experiments support the translation of a range of novel human open
reading frames. By contrast, most peptides from large-scale proteomics experiments derive …

Abstract The RAC1-WAVE-Arp2/3 signaling pathway generates branched actin networks
that power lamellipodium protrusion of migrating cells. Feedback is thought to control …

Genomic rearrangements are a hallmark of most childhood tumors, including
medulloblastoma, one of the most common brain tumors in children, but their causes remain …