Abstract Coagulation factor XII (FXII, Hageman factor, EC= 3.4. 21.38) is the zymogen of the
serine protease, factor XIIa (FXIIa). FXII is converted to FXIIa through autoactivation induced …

Factor XII (FXII) is a coagulation protein that is essential for surface-activated blood
coagulation tests but whose deficiency is not associated with bleeding. For over forty years …

The plasma zymogens factor XII (fXII) and factor XI (fXI) contribute to thrombosis in a variety
of mouse models. These proteins serve a limited role in hemostasis, suggesting that …

Contact activation is the surface-induced conversion of factor XII (FXII) zymogen to the
serine protease FXIIa. Blood-circulating FXII binds to negatively charged surfaces and this …

Coagulation factor XII (FXII), a S1A serine protease, was discovered more than fifty years
ago. However, its in vivo functions and its three-dimensional structure started to be disclosed …

Investigations were performed to define the factor XII (FXII) binding site (s) on cultured
endothelial cells (HUVECs). Biotin-or fluorescein isothiocyanate (FITC)–FXII in the presence …

There is mounting evidence that zinc, the second most abundant transition metal in blood, is
an important mediator of haemostasis and thrombosis. Prompted by the observation that …

The contact system is a protease cascade that is initiated by factor XII activation on
cardiovascular cells. The system starts procoagulant and proinflammatory reactions, via the …

Factor XII (FXII) is a protease that is mainly produced in the liver and circulates in plasma as
a single chain zymogen. Following contact with negatively charged surfaces, FXII is …

The plasma proteins factor XII (FXII) and prekallikrein (PK) undergo reciprocal activation to
the proteases FXIIa and kallikrein by a process that is enhanced by surfaces (contact …