Genome-wide association studies (GWAS) for BMI, waist-to-hip ratio, and other adiposity
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …

The worldwide obesity epidemic has been mainly attributed to lifestyle changes. However,
who becomes obese in an obesity-prone environment is largely determined by genetic …

Diet modulates the genetic risk of obesity, but the modulation has been rarely studied using
genetic risk scores (GRSs) in children. Our objectives were to identify single nucleotide …

The main functions of adipose tissue are thought to be storage and mobilization of the
body's energy reserves, active and passive thermoregulation, participation in the spatial …

Background While the genetics of obesity has been well defined, the epigenetics of obesity
is poorly understood. Here, we used a genome-wide approach to identify genes with …

Variants in the gene encoding ankyrin repeat and SOCS box–containing 4 (ASB4) are
linked to human obesity. Here, we characterized the pathways underlying the metabolic …

South Asians are at increased risk for developing type 2 diabetes and cardiovascular
disease at lower body mass index compared to other ancestral groups. Many factors …

A large number of genome-wide association studies, transferability studies, and candidate
gene studies performed in diverse populations around the world have identified gene …

The studies investigating gene–gene and gene–environment (or gene–behavior)
interactions provide valuable insight into the pathomechanisms underlying obese …

The" thrifty gene hypothesis" suggests genetic susceptibility to obesity arises because of
positive selection for alleles that favored fat deposition and survival during famines. We used …