A systems biology view of blood vessel growth and remodelling
Blood travels throughout the body in an extensive network of vessels–arteries, veins and
capillaries. This vascular network is not static, but instead dynamically remodels in response …
capillaries. This vascular network is not static, but instead dynamically remodels in response …
[HTML][HTML] Seek & Destroy, use of targeting peptides for cancer detection and drug delivery
V Le Joncour, P Laakkonen - Bioorganic & medicinal chemistry, 2018 - Elsevier
Accounting for 16 million new cases and 9 million deaths annually, cancer leaves a great
number of patients helpless. It is a complex disease and still a major challenge for the …
number of patients helpless. It is a complex disease and still a major challenge for the …
Matrikines from basement membrane collagens: a new anti-cancer strategy
JC Monboisse, JB Oudart, L Ramont… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Background Tumor microenvironment is a complex system composed of a largely altered
extracellular matrix with different cell types that determine angiogenic responses and tumor …
extracellular matrix with different cell types that determine angiogenic responses and tumor …
Simultaneous blockade of IL-6 and CCL5 signaling for synergistic inhibition of triple-negative breast cancer growth and metastasis
Background Metastatic triple-negative breast cancer (TNBC) is a heterogeneous and
incurable disease. Numerous studies have been conducted to seek molecular targets to …
incurable disease. Numerous studies have been conducted to seek molecular targets to …
Crosstalk between cancer cells and blood endothelial and lymphatic endothelial cells in tumour and organ microenvironment
Tumour and organ microenvironments are crucial for cancer progression and metastasis.
Crosstalk between multiple non-malignant cell types in the microenvironments and cancer …
Crosstalk between multiple non-malignant cell types in the microenvironments and cancer …
Gene delivery nanoparticles to modulate angiogenesis
Angiogenesis is naturally balanced by many pro-and anti-angiogenic factors while an
imbalance of these factors leads to aberrant angiogenesis, which is closely associated with …
imbalance of these factors leads to aberrant angiogenesis, which is closely associated with …
Celecoxib alleviates tamoxifen-instigated angiogenic effects by ROS-dependent VEGF/VEGFR2 autocrine signaling
Background Tamoxifen (TAM) is widely used in the chemotherapy of breast cancer and as a
preventive agent against recurrence after surgery. However, extended TAM administration …
preventive agent against recurrence after surgery. However, extended TAM administration …
Computational systems biology approaches to anti-angiogenic cancer therapeutics
Highlights•Systems biology approaches support drug development efforts.•Models of
angiogenesis aid in testing anti-angiogenic therapeutic strategies.•Models provide novel …
angiogenesis aid in testing anti-angiogenic therapeutic strategies.•Models provide novel …
Synergistic effect of the pro-apoptosis peptide kla-TAT and the cationic anticancer peptide HPRP-A1
C Hu, X Chen, Y Huang, Y Chen - Apoptosis, 2018 - Springer
In this study, a peptide–peptide co-administration therapy between hybrid peptide kla-TAT
and cationic anticancer peptide HPRP-A1 was designed to increase the anticancer activity …
and cationic anticancer peptide HPRP-A1 was designed to increase the anticancer activity …
Inhibition of breast cancer growth and metastasis by a biomimetic peptide
Metastasis is the main cause of mortality in cancer patients. Though there are many anti-
cancer drugs targeting primary tumor growth, anti-metastatic agents are rarely developed …
cancer drugs targeting primary tumor growth, anti-metastatic agents are rarely developed …