Reactive oxygen species continuously assault the structure of DNA resulting in oxidation
and fragmentation of the nucleobases. Both oxidative DNA damage itself and its repair …

Significance: Human apurinic/apyrimidinic endonuclease 1 (APE1, also known as REF-1)
was isolated based on its ability to cleave at AP sites in DNA or activate the DNA binding …

The endoplasmic reticulum (ER) is a multifunctional intracellular organelle, a component of
the cellular reticular network that allows cells to adjust to a wide variety of conditions. The …

Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

Cancer cells frequently develop resistance to chemotherapeutic therapies and targeted
drugs, which has been a significant challenge in cancer management. With the growing …

The success of chemotherapy in cancer treatment is limited by scarce drug delivery to the
tumor and severe side-toxicity. Prolyl hydroxylase domain protein 2 (PHD2) is an …

Oxidative stress contributes to tissue injury in conditions ranging from cardiovascular
disease to stroke, spinal cord injury, neurodegeneration, and perhaps even aging. Yet the …

Many cancer-associated genes are regulated by guanine (G)-rich sequences that are
capable of refolding from the canonical duplex structure to an intrastrand G-quadruplex …

Apurinic/apyrimidinic endonuclease 1/redox effector-1 (Ape1/Ref-1) is the major
apurinic/apyrimidinic (AP) endonuclease in mammalian cells. It functions mainly in the base …

Base excision repair (BER) handles many forms of endogenous DNA damage, and
apurinic/apyrimidinic endonuclease 1 (APE1) is central to this process. Deletion of both …