The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

Regulated fibroblast growth factor (FGF) signalling is a prerequisite for the correct
development and homeostasis of articular cartilage, as evidenced by the fact that aberrant …

Craniosynostosis, defined as the premature fusion of the cranial sutures, presents many
challenges in classification and treatment. At least 20% of cases are caused by specific …

Intramembranous bone growth is achieved through bone formation within a periosteum or
by bone formation at sutures. Sutures are formed during embryonic development at the sites …

Achondroplasia is the most common form of short limb dwarfism in human beings, affecting
more than 250 000 individuals worldwide. More than 95% of patients have the same point …

This guideline for care of children with craniosynostosis was developed by a national
working group with representatives of 11 matrix societies of specialties and the national …

Introduction Craniosynostosis represents premature closure of cranial sutures. Prevalence is
approximately 3.1–6.4 in 10.000 live births, which is reportedly rising. This epidemiologic …

Enlargement of the skull vault occurs by appositional growth at the fibrous joints between the
bones, termed cranial sutures. Relatively little is known about the developmental biology of …

Craniosynostosis is a birth defect characterized by premature fusion of one or more cranial
sutures. We describe the birth prevalence of craniosynostosis and related risk factors among …

OBJECTIVES: We describe the first cohort-based analysis of the impact of genetic disorders
in craniosynostosis. We aimed to refine the understanding of prognoses and pathogenesis …