Patients with type 2 diabetes mellitus (T2DM) are at high risk for macrovascular
complications, which represent the major cause of mortality. Despite effective treatment of …

Genome-wide association studies (GWAS) for BMI, waist-to-hip ratio, and other adiposity
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …

Key questions in COVID-19 are the duration and determinants of infectious virus shedding.
Here, we report that infectious virus shedding is detected by virus cultures in 23 of the 129 …

Background and Aims Cancer‐associated fibroblasts (CAFs) are key players in multicellular,
stromal‐dependent alterations leading to HCC pathogenesis. However, the intricate …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Background: The implications of different adiposity measures on cardiovascular disease
etiology remain unclear. In this article, we quantify and contrast causal associations of …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Background Obesity is a worldwide epidemic that has been associated with a plurality of
diseases in observational studies. The aim of this study was to summarize the evidence from …

Genome-wide discovery efforts have identified more than 500 genetic loci associated with
adiposity traits. The vast majority of these loci were found through large-scale meta-analyses …

Differences between sexes contribute to variation in the levels of fasting glucose and insulin.
Epidemiological studies established a higher prevalence of impaired fasting glucose in men …