Abstract Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the
“programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is …

Diabetic mellitus (DM) is a common degenerative chronic metabolic disease often
accompanied by severe cardiovascular complications (DCCs) as major causes of death in …

PANoptosis, a unique new form of programmed cell death (PCD), is characterized by
pyroptosis, apoptosis, and necroptosis, but it cannot be explained by pyroptosis, apoptosis …

As a serine/threonine protein kinase, receptor-interacting protein 1 (RIP1) plays an important
role in regulating the pathways in programmed cell death. Multifaceted human diseases (eg …

Necroptosis, which is distinct from apoptosis and necrosis, serves a crucial role in ontogeny
and the maintenance of homeostasis. In the last decade, it has been demonstrated that the …

Background. Stanford type A aortic dissection (TAAD) is one of the most life‐threatening
cardiovascular emergencies with high mortality and morbidity, and necroptosis is a newly …

Sirt6, a class III NAD+-dependent deacetylase of the sirtuin family, is a highly specific H3
deacetylase and plays important roles in regulating cellular growth and death. The induction …

Cytokine storms are an important mechanism of sepsis. TNF-α is an important cytokine. As a
regulator of TNF superfamily receptors, RIPK1 not only serves as the basis of the scaffold …

Cardiovascular disease morbidity/mortality are increasing due to an aging population and
the rising prevalence of diabetes and obesity. Therefore, innovative cardioprotective …

Background Preeclampsia (PE) is a serious pregnancy complication that can adversely
affect the mother and fetus. Necroptosis is a recently discovered new form of programmed …