A review of ancestrality and admixture in Latin America and the caribbean focusing on native American and African descendant populations
Genomics can reveal essential features about the demographic evolution of a population
that may not be apparent from historical elements. In recent years, there has been a …
that may not be apparent from historical elements. In recent years, there has been a …
Genomic ancestry and cancer among Latin Americans
Latin American populations, characterized by intricate admixture patterns resulting from the
intermingling of ancestries from European, Native American (NA) Asian, and African …
intermingling of ancestries from European, Native American (NA) Asian, and African …
Yield of genetic association signals from genomes, exomes and imputation in the UK Biobank
Abstract Whole-genome sequencing (WGS), whole-exome sequencing (WES) and array
genotyping with imputation (IMP) are common strategies for assessing genetic variation and …
genotyping with imputation (IMP) are common strategies for assessing genetic variation and …
Rare coding variants in CHRNB2 reduce the likelihood of smoking
VM Rajagopal, K Watanabe, J Mbatchou, A Ayer… - Nature Genetics, 2023 - nature.com
Human genetic studies of smoking behavior have been thus far largely limited to common
variants. Studying rare coding variants has the potential to identify drug targets. We …
variants. Studying rare coding variants has the potential to identify drug targets. We …
Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease
Y Zhao, M Chukanova, KA Kentistou… - Nature Genetics, 2024 - nature.com
Obesity is a major risk factor for many common diseases and has a substantial heritable
component. To identify new genetic determinants, we performed exome-sequence analyses …
component. To identify new genetic determinants, we performed exome-sequence analyses …
Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas
Latin Americans are underrepresented in genetic studies, increasing disparities in
personalized genomic medicine. Despite available genetic data from thousands of Latin …
personalized genomic medicine. Despite available genetic data from thousands of Latin …
Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study
J Berumen, L Orozco, H Gallardo-Rincón… - Biology of Sex …, 2023 - Springer
Background This study investigated the effect of sex and age at type 2 diabetes (T2D)
diagnosis on the influence of T2D-related genes, parental history of T2D, and obesity on …
diagnosis on the influence of T2D-related genes, parental history of T2D, and obesity on …
Trans-ancestry meta-analysis improves performance of genetic scores for multiple adiposity-related traits in East Asian populations
Z Fairhurst-Hunter, K Lin, IY Millwood, A Pozarickij… - medRxiv, 2022 - medrxiv.org
Genome-wide association studies (GWAS) in predominately European-ancestry (EUR)
populations have identified numerous genetic variants associated with adiposity-related …
populations have identified numerous genetic variants associated with adiposity-related …
Ancestry-dependent genetic structure of the Xq28 risk haplotype in the Mexican population and its association with childhood-onset systemic lupus erythematosus
H García-Ortiz, F Barajas-Olmos… - Frontiers in …, 2023 - frontiersin.org
Objective Here we aimed to investigate the association of the Xq28 risk haplotype (H1) with
susceptibility to childhood-onset systemic lupus erythematosus (SLE), and to compare its …
susceptibility to childhood-onset systemic lupus erythematosus (SLE), and to compare its …