Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an
increasing major health care problem around the world. It is now abundantly clear that both …

Over the last decade, virologists have discovered an unprecedented number of viruses
using high throughput sequencing (HTS), which led to the advancement of our knowledge …

Abstract As NLM's Conserved Domain Database (CDD) enters its 20th year of operations as
a publicly available resource, CDD curation staff continues to develop hierarchical …

Summary Background In late December, 2019, patients presenting with viral pneumonia
due to an unidentified microbial agent were reported in Wuhan, China. A novel coronavirus …

Abstract PubChem (https://pubchem. ncbi. nlm. nih. gov) is a key chemical information
resource for the biomedical research community. Substantial improvements were made in …

Abstract The InterPro database (http://www. ebi. ac. uk/interpro/) classifies protein
sequences into families and predicts the presence of functionally important domains and …

Bacteria and archaea are frequently attacked by viruses and other mobile genetic elements
and rely on dedicated antiviral defense systems, such as restriction endonucleases and …

We developed a prokaryotic genome annotation pipeline, DFAST, that also supports
genome submission to public sequence databases. DFAST was originally started as an on …

Abstract The Reference Sequence (RefSeq) project at the National Center for Biotechnology
Information (NCBI) provides annotation for over 95 000 prokaryotic genomes that meet …

We have made several steps toward creating a fast and accurate algorithm for gene
prediction in eukaryotic genomes. First, we introduced an automated method for efficient ab …