Modeling influenza virus infection: a roadmap for influenza research

A Boianelli, VK Nguyen, T Ebensen, K Schulze, E Wilk… - Viruses, 2015 - mdpi.com
Influenza A virus (IAV) infection represents a global threat causing seasonal outbreaks and
pandemics. Additionally, secondary bacterial infections, caused mainly by Streptococcus …

[HTML][HTML] Giving the genes a shuffle: using natural variation to understand host genetic contributions to viral infections

SR Leist, RS Baric - Trends in Genetics, 2018 - cell.com
The laboratory mouse has proved an invaluable model to identify host factors that regulate
the progression and outcome of virus-induced disease. The paradigm is to use single-gene …

[HTML][HTML] Deletion of Irf3 and Irf7 genes in mice results in altered interferon pathway activation and granulocyte-dominated inflammatory responses to influenza A …

B Hatesuer, HTT Hoang, P Riese, S Trittel… - Journal of innate …, 2017 - karger.com
The interferon (IFN) pathway plays an essential role in the innate immune response
following viral infections and subsequent shaping of adaptive immunity. Infections with …

Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice

SR Leist, C Pilzner, JMA van den Brand, L Dengler… - BMC genomics, 2016 - Springer
Background Influenza A virus is a zoonotic pathogen that poses a major threat to human and
animal health. The severe course of influenza infection is not only influenced by viral …

Host genetic diversity influences the severity of Pseudomonas aeruginosa pneumonia in the Collaborative Cross mice

NI Lorè, FA Iraqi, A Bragonzi - BMC genetics, 2015 - Springer
Background Pseudomonas aeruginosa is one of the top three causes of opportunistic
infections in humans. Patients with a compromised immune system, due to …

RNAseq expression analysis of resistant and susceptible mice after influenza A virus infection identifies novel genes associated with virus replication and important for …

E Wilk, AK Pandey, SR Leist, B Hatesuer, M Preusse… - BMC genomics, 2015 - Springer
Background The host response to influenza A infections is strongly influenced by host
genetic factors. Animal models of genetically diverse mouse strains are well suited to identify …

The molecular and evolutionary genetic implications of being truly social for the social insects

TA Linksvayer - Advances in insect physiology, 2015 - Elsevier
The social complexity that characterizes the eusocial insects strongly affects all aspects of
social insect life, including the molecular and evolutionary genetic basis of social insect …

Veterinary medicine and omics (veterinomics): metabolic transition of milk triacylglycerol synthesis in sows from late pregnancy to lactation

Y Lv, W Guan, H Qiao, C Wang, F Chen… - Omics: a journal of …, 2015 - liebertpub.com
Mammalian milk is a key source of lipids, providing not only important calories but also
essential fatty acids. Veterinary medicine and omics systems sciences intersection, termed …

Of mice and men: the host response to influenza virus infection

H Kollmus, C Pilzner, SR Leist, M Heise, R Geffers… - Mammalian …, 2018 - Springer
Influenza virus (IV) infections represent a very serious public health problem. At present, no
established biomarkers exist to support diagnosis for respiratory viral infections and more …

Respiratory mucosal proteome quantification in human influenza infections

T Marion, H Elbahesh, PG Thomas, JP DeVincenzo… - PLoS …, 2016 - journals.plos.org
Respiratory influenza virus infections represent a serious threat to human health. Underlying
medical conditions and genetic make-up predispose some influenza patients to more severe …