Although progesterone is a steroid hormone mainly associated with female reproductive
functions, such as uterine receptivity and maintenance of pregnancy, accumulating data …

The role of progesterone goes beyond the maintenance of pregnancy. The hormone,
indeed, protects the developing fetal brain and influences its maturation. Metabolomes …

The mesenchymal phenotype of glioblastoma multiforme (GBM), the most frequent and
malignant brain tumor, is associated with the worst prognosis. The epithelial–mesenchymal …

Histamine has neurotransmitter/neuromodulator functions in the adult brain, but its role
during CNS development has been elusive. We studied histamine effects on proliferation …

Embryonic stem (ES) cells can be induced to differentiate into motor neurons (MN). Animal
models resembling MN degeneration and paralysis observed in familial amyotrophic lateral …

Background: Numerous psychiatric and behavioral disorders such as autism, attention
deficit disorder and schizophrenia may involve disruptions in the development of the …

In rodents and nonhuman primates, sex hormones are powerful modulators of dopamine
(DA) neurotransmission. Yet less is known about hormonal regulation of the DA system in …

Histamine in the adult central nervous system (CNS) acts as a neurotransmitter. This amine
is one of the first neurotransmitters to appear during development reaching its maximum …

Progesterone participates in the regulation of several functions in mammals, including brain
differentiation and dopaminergic transmission, but the role of progesterone in dopaminergic …

Embryonic stem (ES) cells have the capacity to differentiate into endodermal, mesodermal,
and ectodermal lineages. Motor neuron (MN) differentiation of mouse ES cells involves …