The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …

Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

This tutorial review covers the recent advances made in the study of gold complexes
containing N-heterocyclic carbene ligands with biological properties. The great stability …

The successful isolation and characterization of an N-heterocyclic carbene in 1991 opened
up a new class of organic compounds for investigation. From these beginnings as academic …

N-heterocyclic carbenes (NHCs) represent one of the most important organic ligands in
coordination chemistry, and have been recently attracting increasing attention in …

Gold complexes have recently gained increasing attention in the design of new metal-based
anticancer therapeutics. Gold (III) complexes are generally reactive/unstable under …

The clinical success of platinum-based chemotherapeutic agents was of enormous impact
on the discovery of novel metal N-heterocyclic carbene (NHC) complexes as potential anti …

Metallodrugs offer potential for unique mechanisms of drug action based on the choice of
the metal, its oxidation state, the types and number of coordinated ligands and the …

Antimicrobial resistance (AMR) is one of the greatest global health challenges of modern
times and its prevalence is rising worldwide. AMR within bacteria reduces the efficacy of …

The quest for alternative drugs to the well-known cisplatin and its derivatives, which are still
used in more than 50% of the treatment regimes for patients suffering from cancer, is highly …