Blood groups in infection and host susceptibility

L Cooling - Clinical microbiology reviews, 2015 - Am Soc Microbiol
Blood group antigens represent polymorphic traits inherited among individuals and
populations. At present, there are 34 recognized human blood groups and hundreds of …

Advances in the development of antiviral strategies against parvovirus B19

E Manaresi, G Gallinella - Viruses, 2019 - mdpi.com
Parvovirus B19 (B19V) is a human pathogenic virus, responsible for an ample range of
clinical manifestations. Infections are usually mild, self-limiting, and controlled by the …

RBCs as targets of infection

J McCullough - Hematology 2014, the American Society of …, 2014 - ashpublications.org
RBCs can be targets of infection directly or indirectly. When the microorganism enters the
RBC directly, RBC damage becomes a fundamental aspect of the disease process. Malaria …

Histo-blood group glycans in the context of personalized medicine

V Dotz, M Wuhrer - Biochimica et Biophysica Acta (BBA)-General Subjects, 2016 - Elsevier
Background A subset of histo-blood group antigens including ABO and Lewis are
oligosaccharide structures which may be conjugated to lipids or proteins. They are known to …

Human Gb3/CD77 synthase produces P1 glycotope-capped N-glycans, which mediate Shiga toxin 1 but not Shiga toxin 2 cell entry

K Szymczak-Kulus, S Weidler, A Bereznicka… - Journal of Biological …, 2021 - ASBMB
The human Gb3/CD77 synthase, encoded by the A4GALT gene, is an unusually
promiscuous glycosyltransferase. It synthesizes the Galα1→ 4Gal linkage on two different …

Multidisciplinary management of anti‐PP1Pk or anti‐P alloimmunization during pregnancy: A new case with anti‐P and a literature review

MS Lépine, V Goua, OS Debouverie, C Giraud… - …, 2021 - Wiley Online Library
Background Red blood cell alloimmunization is the first cause of fetal and neonatal anemia.
Alloimmunizations with anti‐PP1Pk or anti‐P can cause recurrent miscarriages and …

The differential expression of the blood group P1A4GALT and P2A4GALT alleles is stimulated by the transcription factor early growth response 1

CC Yeh, CJ Chang, YC Twu, ST Hung, YJ Tsai… - …, 2018 - Wiley Online Library
BACKGROUND The P1/P2 phenotypic polymorphism is one of the earliest blood groups
discovered in humans. These blood groups have been connected to different levels of …

Human Gb3/CD77 synthase: a glycosyltransferase at the crossroads of immunohematology, toxicology, and cancer research

K Szymczak-Kulus, M Czerwinski… - Cellular & Molecular …, 2024 - Springer
Abstract Human Gb3/CD77 synthase (α1, 4-galactosyltransferase, P1/Pk synthase, UDP-
galactose: β-d-galactosyl-β1-R 4-α-d-galactosyltransferase, EC 2.4. 1.228) forms Galα1→ …

Human Gb3/CD77 synthase reveals specificity toward two or four different acceptors depending on amino acid at position 211, creating Pk, P1 and NOR blood group …

R Kaczmarek, M Duk, K Szymczak… - Biochemical and …, 2016 - Elsevier
Abstract Human Gb3/CD77 synthase (α1, 4-galactosyltransferase, P k synthase), encoded
by A4GALT gene, is known for synthesis of Gal (α1-4) Gal moiety in globotriaosylceramide …

Microbial lectome versus host glycolipidome: How pathogens exploit glycosphingolipids to invade, dupe or kill

A Bereznicka, K Mikolajczyk, M Czerwinski… - Frontiers in …, 2022 - frontiersin.org
Glycosphingolipids (GSLs) are ubiquitous components of the cell membranes, found across
several kingdoms of life, from bacteria to mammals, including humans. GSLs are a subclass …