Type 2 diabetes mellitus (T2DM) continues to be a substantial medical problem due to its
increasing global prevalence and because chronic hyperglycemic states are closely linked …

Hundred years after the discovery of glucagon, its biology remains enigmatic. Accurate
measurement of glucagon has been essential for uncovering its pathological hypersecretion …

Glucagon and insulin are the main regulators of blood glucose. While the actions of insulin
are extensively mapped, less is known about glucagon. Besides glucagon's role in glucose …

Diabetes is characterized by hyperglycemia, loss of functional islet beta cell mass,
deficiency of glucose-lowering insulin, and persistent alpha cell secretion of gluconeogenic …

Abstract Glucagon-like peptide-1 (GLP-1) receptor agonists currently occupy a privileged
place in the management of type-2 diabetes (T2D). Dual glucose-dependent insulinotropic …

Summary 2022 corresponds to the 100th anniversary of the discovery of glucagon. This
TimeCapsule aims to recall the main steps leading to the discovery, characterisation, and …

The liver, the largest solid visceral organ of the body, has numerous endocrine functions,
such as direct hormone and hepatokine production, hormone metabolism, synthesis of …

G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and
an important class of drug targets, play a role in maintaining numerous physiological …

Pancreatic α-cells are the major source of glucagon, a hormone that counteracts the
hypoglycemic action of insulin and strongly contributes to the correction of acute …

Abstract According to the World Health Organization, 422 million adults worldwide live with
diabetes mellitus (DM), a significant portion of whom have type 2 diabetes. The discovery of …