[HTML][HTML] A weight of evidence review of the genotoxicity of titanium dioxide (TiO2)

D Kirkland, MJ Aardema, RV Battersby… - Regulatory Toxicology …, 2022 - Elsevier
Titanium dioxide is a ubiquitous white material found in a diverse range of products from
foods to sunscreens, as a pigment and thickener, amongst other uses. Titanium dioxide has …

Genotoxicity of graphene-based materials

J Domenech, A Rodríguez-Garraus, A López de Cerain… - Nanomaterials, 2022 - mdpi.com
Graphene-based materials (GBMs) are a broad family of novel carbon-based nanomaterials
with many nanotechnology applications. The increasing market of GBMs raises concerns on …

Safety assessment of titanium dioxide (E171) as a food additive

EFSA Panel on Food Additives and Flavourings … - Efsa …, 2021 - Wiley Online Library
The present opinion deals with an updated safety assessment of the food additive titanium
dioxide (E 171) based on new relevant scientific evidence considered by the Panel to be …

The state of the art and challenges of in vitro methods for human hazard assessment of nanomaterials in the context of safe-by-design

N Ruijter, LG Soeteman-Hernández, M Carrière… - Nanomaterials, 2023 - mdpi.com
The Safe-by-Design (SbD) concept aims to facilitate the development of safer
materials/products, safer production, and safer use and end-of-life by performing timely SbD …

[HTML][HTML] Toxicity evaluation of particles formed during 3D-printing: Cytotoxic, genotoxic, and inflammatory response in lung and macrophage models

NVS Vallabani, A Alijagic, A Persson, I Odnevall… - Toxicology, 2022 - Elsevier
Abstract Additive manufacturing (AM) or “3D-printing” is a ground-breaking technology that
enables the production of complex 3D parts. Its rapid growth calls for immediate …

An Adverse Outcome Pathway for food nanomaterial-induced intestinal barrier disruption

D Stanco, D Lipsa, A Bogni… - Frontiers in …, 2024 - frontiersin.org
Introduction The ingestion of nanomaterials (NMs) may impair the intestinal barrier, but the
underlying mechanisms remain evasive, and evidence has not been systematically …

Screening the micronucleus assay for reliable estimation of the genotoxicity of graphene and other 2D materials

S García-Carpintero, VJ González, J Frontiñán-Rubio… - Carbon, 2023 - Elsevier
In recent years, the genotoxicity of graphene-related materials (GRMs) and other 2D
materials has been evaluated using different models to ensure their safety. The OECD TG …

Assessing the Genotoxicity of Cellulose Nanomaterials in a Co-Culture of Human Lung Epithelial Cells and Monocyte-Derived Macrophages

C Ventura, F Pinto, AF Lourenço, JFS Pedrosa… - Bioengineering, 2023 - mdpi.com
Cellulose micro/nanomaterials (CMNMs) are innovative materials with a wide spectrum of
industrial and biomedical applications. Although cellulose has been recognized as a safe …

Safety of Innovative Nanotechnology Oral Formulations Loaded with Bioactive Menopause Molecules: Influence of Genotoxicity and Biochemical Parameters on a …

S Crișan, AL Pop, I Lacatusu, N Badea, C Mustaciosu… - Nutrients, 2023 - mdpi.com
In recent years, nanoparticles have gained significant importance due to their unique
properties, such as pharmacological, electrical, optical, and magnetic abilities, contributing …

Primary and secondary genotoxicity of nanoparticles: Establishing a co-culture protocol for assessing micronucleus using flow cytometry

NVS Vallabani, HL Karlsson - Frontiers in Toxicology, 2022 - frontiersin.org
Genotoxicity is an important endpoint to assess for understanding the risks associated with
nanoparticles (NPs). Most genotoxicity studies performed on NPs have focused on primary …