Non-Alcoholic Fatty Liver Disease (NAFLD) is now the most prevalent form of chronic liver
disease, affecting 10%–20% of the general paediatric population. Within the next 10 years it …

Genetic porphyrias comprise eight diseases caused by defects in the heme biosynthetic
pathway that lead to accumulation of heme precursors. Consequences of porphyria include …

Numerous liver diseases are associated with extensive oxidative tissue damage. It is well
established that Wnt/β-catenin signaling directs multiple hepatocellular processes, including …

BACKGROUND & AIMS: Physiological changes that occur during puberty might affect
pathologic features of nonalcoholic fatty liver disease (NAFLD). We investigated …

Sequestosome 1 (SQSTM1/p62; hereafter p62) is an autophagy receptor protein for
selective autophagy primarily due to its direct interaction with the microtubule light chain 3 …

Tubular aggregates are inclusions, usually found in type II muscle fibers and in males,
consisting of regular arrays of tubules derived from the sarcoplasmic reticulum. Tubular …

Nonalcoholic fatty liver disease (NAFLD) has emerged as the most prevalent chronic liver
disease. Nonalcoholic steatohepatitis (NASH), the more severe form of NAFLD, has an …

Cholestasis is characterized by intrahepatic accumulation of bile acids (BAs), resulting in
liver injury, fibrosis, and liver failure. To date, only ursodeoxycholic acid and obeticholic acid …

Keratin polypeptide 8 (K8) associates noncovalently with its partners K18 and/or K19 to form
the intermediate filament cytoskeleton of hepatocytes and other simple-type epithelial cells …

Background & Aims Porphyrias result from anomalies of heme biosynthetic enzymes and
can lead to cirrhosis and hepatocellular cancer. In mice, these diseases can be modeled by …