Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: Synthetic approaches and multifarious applications
Drug development has been a principal driving force in the rapid maturation of the field of
medicinal chemistry during the past several decades. During this period, the intriguing and …
medicinal chemistry during the past several decades. During this period, the intriguing and …
Quinazolines: new horizons in anticonvulsant therapy
VG Ugale, SB Bari - European journal of medicinal chemistry, 2014 - Elsevier
The search for novel anticonvulsants with more selectivity and lower toxicity continues to be
an area of intensive investigation in medicinal chemistry. The potency and selectivity in the …
an area of intensive investigation in medicinal chemistry. The potency and selectivity in the …
Discovery of a novel series of substituted quinolines acting as anticancer agents and selective EGFR blocker: Molecular docking study
Abstract A Ta 2 O 5-anchored-piperidine-4-carboxylic acid (PPCA) nanoparticle has been
synthesized and characterized. It was then used as a highly effective nanocatalyst for the …
synthesized and characterized. It was then used as a highly effective nanocatalyst for the …
Design, synthesis, anticancer activity and docking studies of novel quinazoline-based thiazole derivatives as EGFR kinase inhibitors
The in vitro anticancer efficacy of a new series of quinazoline-based thiazole derivatives was
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
Phytol in a pharma-medico-stance
MT Islam, MVOB de Alencar… - Chemico-Biological …, 2015 - Elsevier
This study aims to review phytol (PYT), through published articles, periodicals, magazines
and patents, which were retrieved from the PM, SD, WS, SP; DII, WIPO, CIPO, USPTO and …
and patents, which were retrieved from the PM, SD, WS, SP; DII, WIPO, CIPO, USPTO and …
Experimental and theoretical examinations of triazole linked saccharin derivatives as organic corrosion inhibitors for mild steel in hydrochloric acid
The new triazole linked saccharin derivatives namely, 2-(3-methyl-1H-1, 2, 4-triazol-5-yl)
benzo [d] isothiazol-3 (2H)-one 1, 1-dioxide (MTD) and 2-(3-isopropyl-1H-1, 2, 4-triazol-5-yl) …
benzo [d] isothiazol-3 (2H)-one 1, 1-dioxide (MTD) and 2-(3-isopropyl-1H-1, 2, 4-triazol-5-yl) …
Click synthesis of 1, 2, 3-triazole based imidazoles: Antitubercular evaluation, molecular docking and HSA binding studies
CBP Kumar, BS Prathibha, KNN Prasad… - Bioorganic & Medicinal …, 2021 - Elsevier
Using Cu (I)-catalyzed cycloaddition of alkyne and azide reaction (CuAAC), a series of novel
1, 2, 3-triazole based imidazole derivatives (3a-e) have been synthesized. The synthesized …
1, 2, 3-triazole based imidazole derivatives (3a-e) have been synthesized. The synthesized …
Current perspectives on quinazolines with potent biological activities: A review
Quinazoline is a heterocyclic compound having biological activities. It is aromatic in nature
having bicyclic structure containing benzene ring and pyrimidine ring. Quinazoline and its …
having bicyclic structure containing benzene ring and pyrimidine ring. Quinazoline and its …
Investigation of biological activity of 2, 3-disubstituted quinazolin-4 (1 H)-ones against Mycobacterium tuberculosis and DNA via docking, spectroscopy and DFT …
A series of 2, 3-disubstituted quinazolin-4 (1H)-ones (3a–j) were screened for their
antimicrobial activity via the minimum inhibitory concentration method (MIC). The in vitro anti …
antimicrobial activity via the minimum inhibitory concentration method (MIC). The in vitro anti …
Design, synthesis and anticonvulsant evaluation of N-(benzo [d] thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3 (4H)-carbothioamide derivatives: A hybrid …
S Malik, RS Bahare, SA Khan - European Journal of Medicinal Chemistry, 2013 - Elsevier
Abstract Novel N-(benzo [d] thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3 (4H)-
carbothioamide derivatives were synthesized and evaluation of their anticonvulsant effects …
carbothioamide derivatives were synthesized and evaluation of their anticonvulsant effects …