Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

Histone variants endow chromatin with unique properties and show a specific genomic
distribution that is regulated by specific deposition and removal machineries. These variants …

The function of sperm is to safely transport the haploid paternal genome to the egg
containing the maternal genome. The subsequent fertilization leads to transmission of a new …

Despite a conserved role for histones as general DNA packaging agents, it is now clear that
another key function of these proteins is to confer variations in chromatin structure to ensure …

Histone proteins wrap DNA to form nucleosome particles that compact eukaryotic genomes
while still allowing access for cellular processes such as transcription, replication and DNA …

Histone variants are non-allelic protein isoforms that play key roles in diversifying chromatin
structure. The known number of such variants has greatly increased in recent years, but the …

In this review, we describe the attributes of histone H3 mutants identified in cancer. H3
mutants were first identified in genes encoding H3. 3, in pediatric high-grade glioma, and …

Histone variants are emerging as key regulatory molecules in cancer. We report a unique
role for the H2A. Z isoform H2A. Z. 2 as a driver of malignant melanoma. H2A. Z. 2 is highly …

TDP-43 and FUS are nuclear proteins with multiple functions in mRNA processing. They
play key roles in ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) …

Histones have a long history of research in a wide range of species, leaving a legacy of
complex nomenclature in the literature. Community-led discussions at the EMBO Workshop …