Moving beyond the glial scar for spinal cord repair

EJ Bradbury, ER Burnside - Nature communications, 2019 - nature.com
Traumatic spinal cord injury results in severe and irreversible loss of function. The injury
triggers a complex cascade of inflammatory and pathological processes, culminating in …

Current advancements in spinal cord Injury Research—glial scar formation and neural regeneration

T Clifford, Z Finkel, B Rodriguez, A Joseph, L Cai - Cells, 2023 - mdpi.com
Spinal cord injury (SCI) is a complex tissue injury resulting in permanent and degenerating
damage to the central nervous system (CNS). Detrimental cellular processes occur after SCI …

Three-dimensional-cultured MSC-derived exosome-hydrogel hybrid microneedle array patch for spinal cord repair

M Han, H Yang, X Lu, Y Li, Z Liu, F Li, Z Shang… - Nano …, 2022 - ACS Publications
Exosomes derived from mesenchymal stem cells (MSCs) have been proven to exhibit great
potentials in spinal cord injury (SCI) therapy. However, conventional two-dimensional (2D) …

Microenvironment imbalance of spinal cord injury

B Fan, Z Wei, X Yao, G Shi, X Cheng… - Cell …, 2018 - journals.sagepub.com
Spinal cord injury (SCI), for which there currently is no cure, is a heavy burden on patient
physiology and psychology. The microenvironment of the injured spinal cord is complicated …

Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications

K Venkatesh, SK Ghosh, M Mullick… - Cell and tissue …, 2019 - Springer
Axonal regeneration and formation of tripartite (axo-glial) junctions at damaged sites is a
prerequisite for early repair of injured spinal cord. Transplantation of stem cells at such sites …

Myelin damage and repair in pathologic CNS: challenges and prospects

A Alizadeh, SM Dyck… - Frontiers in molecular …, 2015 - frontiersin.org
Injury to the central nervous system (CNS) results in oligodendrocyte cell death and
progressive demyelination. Demyelinated axons undergo considerable physiological …

[HTML][HTML] The role of PI3K/Akt signalling pathway in spinal cord injury

CL Xiao, WC Yin, YC Zhong, JQ Luo, LL Liu… - Biomedicine & …, 2022 - Elsevier
Spinal cord injury (SCI) is a severely disabling central nervous system injury with complex
pathological mechanisms that leads to sensory and motor dysfunction. The current treatment …

Diversity of reactive astrogliosis in CNS pathology: heterogeneity or plasticity?

AJ Moulson, JW Squair, RJM Franklin… - Frontiers in cellular …, 2021 - frontiersin.org
Astrocytes are essential for the development and homeostatic maintenance of the central
nervous system (CNS). They are also critical players in the CNS injury response during …

Multimodal treatment for spinal cord injury: a sword of neuroregeneration upon neuromodulation

Y Zheng, YR Mao, TF Yuan, DS Xu… - Neural regeneration …, 2020 - journals.lww.com
Spinal cord injury is linked to the interruption of neural pathways, which results in
irreversible neural dysfunction. Neural repair and neuroregeneration are critical goals and …

Regulating endogenous neural stem cell activation to promote spinal cord injury repair

EAB Gilbert, N Lakshman, KSK Lau, CM Morshead - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) affects millions of individuals worldwide. Currently, there is no cure,
and treatment options to promote neural recovery are limited. An innovative approach to …