A variety of barriers ensures the protection of the peripheral nervous system from noxious
blood-borne or surrounding stimuli. In this review, anatomy and functioning of the blood …

Although descriptions of quality of life and patient reports of mood in sickle cell disease
(SCD) have become more common in the literature, less is known about psychiatric illness …

Sickle cell disease is a uniquely complex painful disease, with lifelong episodes of
unpredictable acute pain and superimposed chronic pain in adulthood. Both painful crises …

The root cause of sickle cell disease (SCD) has been known for nearly a century, however,
few therapies to treat the disease are available. Over several decades of work, with …

Pain has been recognized as the clinical hallmark of sickle cell disease (SCD) since its
initial description in the Western medical literature more than 100 years ago. Clinical and …

Background and Objectives Patients with sickle cell disease (SCD) are prone to
symptomatic neurologic complications. Previous studies reported accrual of neural injury …

Patients with Fabry disease suffer from chronic debilitating pain and peripheral sensory
neuropathy with minimal treatment options, but the cellular drivers of this pain are unknown …

Fabry disease (FD) causes life-long pain, the mechanisms of which are unclear. Patients
with FD have chronic pain that mirrors symptoms of other painful peripheral neuropathies …

Introduction Opioids are used for acute and chronic pain in patients with sickle cell disease.
How outpatient opioid regimens relate to acute care visits is of interest given the risks of high …

Background Neuropathic pain (NP) has been previously explored in adolescents with sickle
cell disease (SCD). This study aims to describe the prevalence of NP in adolescents with …