Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling
SB Shears - Journal of cellular physiology, 2018 - Wiley Online Library
Inositol pyrophosphates are small, diffusible signaling molecules that possess the most
concentrated three‐dimensional array of phosphate groups in Nature; up to eight …
concentrated three‐dimensional array of phosphate groups in Nature; up to eight …
The inositol pyrophosphate pathway in health and diseases
A Chakraborty - Biological Reviews, 2018 - Wiley Online Library
Inositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds
and fungi to mammals. Distinct classes of kinases generate different forms of energetic …
and fungi to mammals. Distinct classes of kinases generate different forms of energetic …
Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues
Technical challenges have to date prevented a complete profiling of the levels of myo-
inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) in mammalian tissues. Here, we …
inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) in mammalian tissues. Here, we …
[HTML][HTML] Versatile signaling mechanisms of inositol pyrophosphates
MN Trung, D Furkert, D Fiedler - Current opinion in chemical biology, 2022 - Elsevier
Inositol pyrophosphates (PP-InsPs) constitute a group of highly charged messengers, which
regulate central biological processes in health and disease, such as cellular phosphate and …
regulate central biological processes in health and disease, such as cellular phosphate and …
Reversing ROS‐mediated neurotoxicity by chlorogenic acid involves its direct antioxidant activity and activation of Nrf2‐ARE signaling pathway
Chlorogenic acid (CA), the ester of caffeic acid and quinic acid, is one of the most abundant
polyphenols in coffee, and has multiple pharmacological functions. The present study is …
polyphenols in coffee, and has multiple pharmacological functions. The present study is …
Identity and functions of inorganic and inositol polyphosphates in plants
L Lorenzo‐Orts, D Couto, M Hothorn - New Phytologist, 2020 - Wiley Online Library
Inorganic polyphosphates (polyPs) and inositol pyrophosphates (PP‐InsPs) form important
stores of inorganic phosphate and can act as energy metabolites and signaling molecules …
stores of inorganic phosphate and can act as energy metabolites and signaling molecules …
Inositol Pyrophosphates as Versatile Metabolic Messengers
Discovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling
metabolites whose versatile modes of action are being increasingly appreciated. These …
metabolites whose versatile modes of action are being increasingly appreciated. These …
Inositol polyphosphates intersect with signaling and metabolic networks via two distinct mechanisms
Inositol-based signaling molecules are central eukaryotic messengers and include the
highly phosphorylated, diffusible inositol polyphosphates (InsPs) and inositol …
highly phosphorylated, diffusible inositol polyphosphates (InsPs) and inositol …
The yeast AMP-activated protein kinase Snf1 phosphorylates the inositol polyphosphate kinase Kcs1
S Sunder, JS Bauman, SJ Decker, AR Lifton… - Journal of Biological …, 2024 - ASBMB
The yeast Snf1/AMP-activated kinase (AMPK) maintains energy homeostasis, controlling
metabolic processes and glucose derepression in response to nutrient levels and …
metabolic processes and glucose derepression in response to nutrient levels and …
Inositol pyrophosphates: signaling molecules with pleiotropic actions in mammals
Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7)
are inositol metabolites containing high-energy phosphoanhydride bonds. Biosynthesis of …
are inositol metabolites containing high-energy phosphoanhydride bonds. Biosynthesis of …