Mitochondria and the dynamic control of stem cell homeostasis
The maintenance of cellular identity requires continuous adaptation to environmental
changes. This process is particularly critical for stem cells, which need to preserve their …
changes. This process is particularly critical for stem cells, which need to preserve their …
The role of endoplasmic reticulum and mitochondria in maintaining redox status and glycolytic metabolism in pluripotent stem cells
S Babaei-Abraki, F Karamali… - Stem Cell Reviews and …, 2022 - Springer
Pluripotent stem cells (PSCs), including embryonic stem cells and induced pluripotent stem
cells (iPSCs), can be applicable for regenerative medicine. They strangely rely on glycolysis …
cells (iPSCs), can be applicable for regenerative medicine. They strangely rely on glycolysis …
OCIAD1 controls electron transport chain complex I activity to regulate energy metabolism in human pluripotent stem cells
DK Shetty, KP Kalamkar, MS Inamdar - Stem Cell Reports, 2018 - cell.com
Pluripotent stem cells (PSCs) derive energy predominantly from glycolysis and not the
energy-efficient oxidative phosphorylation (OXPHOS). Differentiation is initiated with energy …
energy-efficient oxidative phosphorylation (OXPHOS). Differentiation is initiated with energy …
Culturing and transcriptome profiling of progenitor-like colonies derived from adult mouse pancreas
D Ma, S Tang, J Song, Q Wu, F Zhang, Y Xing… - Stem Cell Research & …, 2017 - Springer
Background Transplantation of insulin-producing cells is considered an important diabetes
therapy. Many research studies have shown that insulin-producing cells can be derived from …
therapy. Many research studies have shown that insulin-producing cells can be derived from …
Global transcriptomic analysis of induced cardiomyocytes predicts novel regulators for direct cardiac reprogramming
Heart diseases are the most significant cause of morbidity and mortality in the world. De
novo generated cardiomyocytes (CMs) are a great cellular source for cell-based therapy and …
novo generated cardiomyocytes (CMs) are a great cellular source for cell-based therapy and …
iPSC-derived neurons from patients with POLG mutations exhibit decreased mitochondrial content and dendrite simplification
Mutations in POLG, the gene encoding the catalytic subunit of DNA polymerase gamma,
result in clinical syndromes characterized by mitochondrial DNA (mtDNA) depletion in …
result in clinical syndromes characterized by mitochondrial DNA (mtDNA) depletion in …
Assessment of neurometabolic dysfunction and editing mitochondrial genome in the context of leigh syndrome by using induced pluripotent stem cell models
RB Pereira - 2022 - repositorio.ul.pt
Leigh Syndrome (LS) is a rare and complex mitochondrial disorder that usually starts during
childhood. It is caused by damage in energy production due to mutations in the nuclear …
childhood. It is caused by damage in energy production due to mutations in the nuclear …
[HTML][HTML] Metabolic plasticity complements the unique nature and demands of distinct pluripotency states
M Popovic, B Heindryckx - Stem Cell Investigation, 2017 - ncbi.nlm.nih.gov
Page 2 of 3 cell-fate specification in both primed and naive hESCs. The authors demonstrate
that shifts in both glycolytic flux and mitochondrial respiration, accompany manipulations of …
that shifts in both glycolytic flux and mitochondrial respiration, accompany manipulations of …