Idiopathic inflammatory myopathies are a group of autoimmune diseases with a broad
spectrum of clinical presentations, primarily characterised by immune-mediated muscle …

Inclusion body myositis (IBM) is a late onset sporadic myopathy with a characteristic clinical
presentation, but as yet unknown aetiology or effective treatment. Typical clinical features …

Background Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder
leading to muscle weakness and respiratory failure. Arimoclomol, a heat-shock protein-70 …

Sporadic inclusion body myositis (IBM) is a progressive condition which commonly affects
patients aged above 40. IBM does not respond to immunosuppression and no proven …

The discovery, over the last forty years or so, of specific myositis auto-antibodies (easily
dosed in routine nowadays) and the fine clinically and pathologically phenotypic …

Muscle diseases cover a diverse group of disorders that, in most cases, are hereditary. The
rarity of the individual muscle diseases provides a challenge for researchers when wanting …

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Since the publication of the 2013 European Neuromuscular Center (ENMC) diagnostic
criteria for Inclusion Body Myositis (IBM), several advances have been made regarding IBM …

Background: Sporadic inclusion body myositis (sIBM) is the predominant idiopathic
inflammatory myopathy (IIM) in older people. Limitations of classical clinical assessments …

Inclusion body myositis (IBM) remains an enigmatic and complex muscle disorder where a
deeper understanding of disease pathomechanisms and the identification of potential …