Chemical approaches to carbocyclic nucleosides
AC Ojeda‐Porras, V Roy… - The Chemical Record, 2022 - Wiley Online Library
Nucleoside analogues are at the forefront of antiviral therapy for last decades. To circumvent
some of their limitations, based on their metabolism, and in order to improve their anti‐viral …
some of their limitations, based on their metabolism, and in order to improve their anti‐viral …
Identification of 6′-β-fluoro-homoaristeromycin as a potent inhibitor of chikungunya virus replication
YS Shin, DB Jarhad, MH Jang, K Kovacikova… - European Journal of …, 2020 - Elsevier
We have reported on aristeromycin (1) and 6′-fluorinated-aristeromycin analogues (2),
which are active against RNA viruses such as Middle East respiratory syndrome coronavirus …
which are active against RNA viruses such as Middle East respiratory syndrome coronavirus …
Design, Synthesis, and Molecular Docking Analysis of Fluorinated MLN4924 Derivatives as Antiviral Agents
K Sung, S Hyeon, M Kim, PK Sahu… - Asian Journal of …, 2023 - Wiley Online Library
MLN4924 is known for its potential in cancer treatment and antiviral activity as a NEDD8‐
activating enzyme (NAE) inhibitor. We designed and synthesized fluorinated MLN4924 …
activating enzyme (NAE) inhibitor. We designed and synthesized fluorinated MLN4924 …
An alternative and efficient synthesis of MLN4924, a selective NEDD8 inhibitor
An efficient synthesis of MLN4924, a small molecule inhibitor of NEDD8-activating enzyme
(NAE) in clinical trial as an anticancer agent, has been accomplished via regioselective α …
(NAE) in clinical trial as an anticancer agent, has been accomplished via regioselective α …