cGAS/STING signalling pathway in senescence and oncogenesis
The cGAS/STING signaling pathway is a crucial component of the innate immune system,
playing significant roles in sensing cytosolic DNA, regulating cellular senescence, and …
playing significant roles in sensing cytosolic DNA, regulating cellular senescence, and …
DNA-sensing pathways in health, autoinflammatory and autoimmune diseases
M Dong, KA Fitzgerald - Nature Immunology, 2024 - nature.com
Detection of microbial DNA is a primary means of host defense. In mammalian cells, DNA-
sensing pathways induce robust anti-microbial responses and initiation of adaptive …
sensing pathways induce robust anti-microbial responses and initiation of adaptive …
Regulation of cGAS–STING signalling and its diversity of cellular outcomes
Z Zhang, C Zhang - Nature Reviews Immunology, 2025 - nature.com
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signalling
pathway, which recognizes both pathogen DNA and host-derived DNA, has emerged as a …
pathway, which recognizes both pathogen DNA and host-derived DNA, has emerged as a …
Free amino acids accelerate the time-dependent inactivation of rat liver nucleotide pyrophosphatase/phosphodiesterase Enpp3 elicited by EDTA
A Romero, G Cumplido-Laso, A Fernández, J Moreno… - Amino Acids, 2025 - Springer
Abstract Nucleotide-pyrophosphatases/phosphodiesterases (NPP/PDE) are membrane or
secreted Zn 2+-metallohydrolases of nucleoside-5-monophosphate derivatives. They …
secreted Zn 2+-metallohydrolases of nucleoside-5-monophosphate derivatives. They …
Protein-protein interactions in cGAS-STING pathway: a medicinal chemistry perspective
SD Zhang, H Li, YL Zhou, XC Liu, DC Li… - Future Medicinal …, 2024 - Taylor & Francis
Protein-protein interactions (PPIs) play pivotal roles in biological processes and are closely
linked with human diseases. Research on small molecule inhibitors targeting PPIs provides …
linked with human diseases. Research on small molecule inhibitors targeting PPIs provides …
cGAS-STING: mechanisms and therapeutic opportunities
M Zhang, C Wu, D Lu, X Wang, G Shang - Science China Life Sciences, 2025 - Springer
The cGAS-STING pathway plays a crucial role in the innate immune system by detecting
mislocalized double-stranded DNA (dsDNA) in the cytoplasm and triggering downstream …
mislocalized double-stranded DNA (dsDNA) in the cytoplasm and triggering downstream …
STING activation and overcoming the challenges associated with STING agonists using ADC (antibody-drug conjugate) and other delivery systems
H Vasiyani, B Wadhwa - Cellular Signalling, 2025 - Elsevier
In current immunotherapy cGAS (cyclic GMP-AMP synthase)-STING (stimulator of interferon
genes) pathway considered as most focused area after CAR-T cell. Exploitation of host …
genes) pathway considered as most focused area after CAR-T cell. Exploitation of host …
ENPP1/CD203a-targeting heavy-chain antibody reveals cell-specific expression on human immune cells
H Lorenz, S Menzel, N Roshchyna, B Albrecht… - Cellular and Molecular …, 2024 - Springer
ENPP1/CD203a is a membrane-bound ectonucleotidase capable of hydrolyzing ATP,
cGAMP and other substrates. Its enzymatic activity plays an important role in the balance of …
cGAMP and other substrates. Its enzymatic activity plays an important role in the balance of …
[HTML][HTML] Structural and Functional Integration of Tissue-Nonspecific Alkaline Phosphatase Within the Alkaline Phosphatase Superfamily: Evolutionary Insights and …
I Imam, GJP Rautureau, S Violot, ED Mulard… - …, 2024 - pmc.ncbi.nlm.nih.gov
Phosphatases are enzymes that catalyze the hydrolysis of phosphate esters. They play
critical roles in diverse biological processes such as extracellular nucleotide homeostasis …
critical roles in diverse biological processes such as extracellular nucleotide homeostasis …