The roles of histone variants in fine-tuning chromatin organization and function
S Martire, LA Banaszynski - Nature reviews Molecular cell biology, 2020 - nature.com
Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …
post-translational modification and chromatin remodelling complexes, histone variants …
The histone variant H2A. Z in gene regulation
BD Giaimo, F Ferrante, A Herchenröther, SB Hake… - Epigenetics & …, 2019 - Springer
The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …
Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer
Endocrine therapy resistance frequently develops in estrogen receptor positive (ER+) breast
cancer, but the underlying molecular mechanisms are largely unknown. Here, we show that …
cancer, but the underlying molecular mechanisms are largely unknown. Here, we show that …
The H2A. Z-nucleosome code in mammals: emerging functions
H2A. Z is a histone variant that provides specific structural and docking-side properties to the
nucleosome, resulting in diverse and specialised molecular and cellular functions. In this …
nucleosome, resulting in diverse and specialised molecular and cellular functions. In this …
Multifunctional histone variants in genome function
LH Wong, DJ Tremethick - Nature Reviews Genetics, 2024 - nature.com
Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …
organization and function of the genome. The dynamic regulation of chromatin involves the …
Integrative comparison of the genomic and transcriptomic landscape between prostate cancer patients of predominantly African or European genetic ancestry
Men of predominantly African Ancestry (AA) have higher prostate cancer (CaP) incidence
and worse survival than men of predominantly European Ancestry (EA). While …
and worse survival than men of predominantly European Ancestry (EA). While …
Now open: evolving insights to the roles of lysine acetylation in chromatin organization and function
Protein acetylation is conserved across phylogeny and has been recognized as one of the
most prominent post-translational modifications since its discovery nearly 60 years ago …
most prominent post-translational modifications since its discovery nearly 60 years ago …
Solid tumours hijack the histone variant network
Cancer is a complex disease characterized by loss of cellular homeostasis through genetic
and epigenetic alterations. Emerging evidence highlights a role for histone variants and their …
and epigenetic alterations. Emerging evidence highlights a role for histone variants and their …
Replication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer
DNA replication timing is known to facilitate the establishment of the epigenome, however,
the intimate connection between replication timing and changes to the genome and …
the intimate connection between replication timing and changes to the genome and …
Post-translational modifications of H2A histone variants and their role in cancer
D Corujo, M Buschbeck - Cancers, 2018 - mdpi.com
Histone variants are chromatin components that replace replication-coupled histones in a
fraction of nucleosomes and confer particular characteristics to chromatin. H2A variants …
fraction of nucleosomes and confer particular characteristics to chromatin. H2A variants …