Epitranscriptome sequencing technologies: decoding RNA modifications
In recent years, major breakthroughs in RNA-modification-mediated regulation of gene
expression have been made, leading to the emerging field of epitranscriptomics. Our …
expression have been made, leading to the emerging field of epitranscriptomics. Our …
Detection technologies for RNA modifications
Y Zhang, L Lu, X Li - Experimental & Molecular Medicine, 2022 - nature.com
To date, more than 170 chemical modifications have been characterized in RNA, providing a
new layer of gene expression regulation termed the 'epitranscriptome'. RNA modification …
new layer of gene expression regulation termed the 'epitranscriptome'. RNA modification …
GAGE: A critical evaluation of genome assemblies and assembly algorithms
New sequencing technology has dramatically altered the landscape of whole-genome
sequencing, allowing scientists to initiate numerous projects to decode the genomes of …
sequencing, allowing scientists to initiate numerous projects to decode the genomes of …
The transcriptional landscape and mutational profile of lung adenocarcinoma
All cancers harbor molecular alterations in their genomes. The transcriptional consequences
of these somatic mutations have not yet been comprehensively explored in lung cancer …
of these somatic mutations have not yet been comprehensively explored in lung cancer …
A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing
The identification of the molecular events that drive cancer transformation is essential to the
development of targeted agents that improve the clinical outcome of lung cancer. Many …
development of targeted agents that improve the clinical outcome of lung cancer. Many …
[HTML][HTML] Reliable identification of genomic variants from RNA-seq data
R Piskol, G Ramaswami, JB Li - The American Journal of Human Genetics, 2013 - cell.com
Identifying genomic variation is a crucial step for unraveling the relationship between
genotype and phenotype and can yield important insights into human diseases. Prevailing …
genotype and phenotype and can yield important insights into human diseases. Prevailing …
Accurate identification of human Alu and non-Alu RNA editing sites
We developed a computational framework to robustly identify RNA editing sites using
transcriptome and genome deep-sequencing data from the same individual. As compared …
transcriptome and genome deep-sequencing data from the same individual. As compared …
Accurate identification of A-to-I RNA editing in human by transcriptome sequencing
JH Bahn, JH Lee, G Li, C Greer, G Peng… - Genome …, 2012 - genome.cshlp.org
RNA editing enhances the diversity of gene products at the post-transcriptional level.
Approaches for genome-wide identification of RNA editing face two main challenges …
Approaches for genome-wide identification of RNA editing face two main challenges …
Principles governing A-to-I RNA editing in the breast cancer transcriptome
D Fumagalli, D Gacquer, F Rothé, A Lefort, F Libert… - Cell reports, 2015 - cell.com
Little is known about how RNA editing operates in cancer. Transcriptome analysis of 68
normal and cancerous breast tissues revealed that the editing enzyme ADAR acts uniformly …
normal and cancerous breast tissues revealed that the editing enzyme ADAR acts uniformly …
ADAR regulates RNA editing, transcript stability, and gene expression
Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine, which is then
recognized as guanosine. To study the role of ADAR proteins in RNA editing and gene …
recognized as guanosine. To study the role of ADAR proteins in RNA editing and gene …