Multi-omics research in sarcopenia: current progress and future prospects

JC Liu, SS Dong, H Shen, DY Yang, BB Chen… - Ageing Research …, 2022 - Elsevier
Sarcopenia is a systemic disease with progressive and generalized skeletal muscle
dysfunction defined by age-related low muscle mass, high content of muscle slow fibers, and …

[HTML][HTML] Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress

A Abulikemu, X Zhao, H Xu, Y Li, R Ma, Q Yao, J Wang… - Redox Biology, 2023 - Elsevier
The metabolic associated fatty liver disease (MAFLD) is a public health challenge, leading to
a global increase in chronic liver disease. The respiratory exposure of silica nanoparticles …

Efficacy and safety of elamipretide in individuals with primary mitochondrial myopathy: the MMPOWER-3 randomized clinical trial

A Karaa, E Bertini, V Carelli, BH Cohen, GM Enns… - Neurology, 2023 - AAN Enterprises
Background and Objectives Primary mitochondrial myopathies (PMMs) encompass a group
of genetic disorders that impair mitochondrial oxidative phosphorylation, adversely affecting …

Improved dried blood spot-based metabolomics: a targeted, broad-spectrum, single-injection method

K Li, JC Naviaux, JM Monk, L Wang, RK Naviaux - Metabolites, 2020 - mdpi.com
Dried blood spots (DBS) have proven to be a powerful sampling and storage method for
newborn screening and many other applications. However, DBS methods have not yet been …

Circulating FGF21 and GDF15 as biomarkers for screening, diagnosis, and severity assessment of primary mitochondrial disorders in children

Y Li, S Li, Y Qiu, M Zhou, M Chen, Y Hu, S Hong… - Frontiers in …, 2022 - frontiersin.org
Background Primary mitochondrial disorders (PMDs) are a diagnostic challenge for
paediatricians, and identification of reliable and easily measurable biomarkers has become …

Loss of muscle carnitine palmitoyltransferase 2 prevents diet-induced obesity and insulin resistance despite long-chain acylcarnitine accumulation

AS Pereyra, A Rajan, CR Ferreira, JM Ellis - Cell reports, 2020 - cell.com
To assess the effects of acylcarnitine accumulation on muscle insulin sensitivity, a model of
muscle acylcarnitine accumulation was generated by deleting carnitine palmitoyltransferase …

[HTML][HTML] Bioenergetic and proteomic profiling of immune cells in myalgic encephalomyelitis/chronic fatigue syndrome patients: an exploratory study

P Fernandez-Guerra, AC Gonzalez-Ebsen, SE Boonen… - Biomolecules, 2021 - mdpi.com
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a heterogeneous,
debilitating, and complex disease. Along with disabling fatigue, ME/CFS presents an array of …

A Distinctive Metabolomics Profile and Potential Biomarkers for Very Long Acylcarnitine Dehydrogenase Deficiency (VLCADD) Diagnosis in Newborns

R Sebaa, RH AlMalki, W Alseraty, AM Abdel Rahman - Metabolites, 2023 - mdpi.com
Very long-chain acylcarnitine dehydrogenase deficiency (VLCADD) is a rare inherited
metabolic disorder associated with fatty acid β-oxidation and characterized by genetic …

[HTML][HTML] Divergence in metabolomic profile in clownfish and damselfish skin mucus

S Heim, T Teav, H Gallart-Ayala, J Ivanisevic… - Frontiers in Ecology …, 2023 - frontiersin.org
The clownfish-sea anemone mutualism was suggested to have triggered the adaptive
radiation of clownfishes, but the origin of clownfish resistance to stinging tentacles of host …

Metabolomic profiles of stony coral species from the Dry Tortugas National Park display inter-and intraspecies variation

JM Deutsch, AM Demko, OA Jaiyesimi, G Foster… - …, 2024 - journals.asm.org
Coral reefs are experiencing unprecedented loss in coral cover due to increased incidence
of disease and bleaching events. Thus, understanding mechanisms of disease susceptibility …