TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated
their epithelial antiproliferative response and benefit from increased TGFβ expression and …

Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the
settlement of a metastatic niche in a second organ. Their role in cancer progression is …

Endometriosis is a common condition in women that causes chronic pain and infertility and
is associated with an elevated risk of ovarian cancer. We profiled transcriptomes of> …

Simple Summary Extracellular vesicles (EVs) are cell-derived membrane-surrounded
vesicles that carry bioactive molecules and deliver them to recipient cells. Classical EVs are …

Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic
acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor …

Blood and lymphatic vasculatures are intimately involved in tissue oxygenation and fluid
homeostasis maintenance. Assembly of these vascular networks involves sprouting …

Extravasated erythrocytes in cerebrospinal fluid (CSF) critically contribute to the
pathogenesis of subarachnoid hemorrhage (SAH). Meningeal lymphatics have been …

Background—The lymphatic system regulates interstitial tissue fluid balance, and lymphatic
malfunction causes edema. The heart has an extensive lymphatic network displaying a …

Gastric cancer is diagnosed in nearly one million new patients each year and it remains the
second leading cause of cancer-related deaths worldwide. Although gastric cancer …

Background Patients with lymph node (LN)-positive pancreatic ductal adenocarcinoma
(PDAC) have extremely poor survival rates. Circular RNAs (circRNAs), a newly discovered …