The corneal endothelium located on the posterior corneal surface is responsible for
regulating stromal hydration. This is contributed by a monolayer of corneal endothelial cells …

Solute-linked cotransporter, SLC4A11, a member of the bicarbonate transporter family, is an
electrogenic H+ transporter activated by NH3 and alkaline pH. Although SLC4A11 does not …

Corneal dystrophies represent a group of heterogeneous hereditary disorders causing
progressive corneal opacification and blindness. Current corneal transplant management for …

Managing pediatric corneal disorders is challenging as the prognosis of pediatric
keratoplasty depends on several factors. Advancements in the genetic basis of congenital …

Corneal endothelial dystrophies are a heterogeneous group of diseases with different
modes of inheritance and genetic basis for each dystrophy. The genes associated with these …

Purpose: There are no defined diagnostic criteria and severity classification for Fuchs
endothelial corneal dystrophy (FECD), which are required for objective standardized …

Introduction The pathogenic role of variants in TCF4 and COL8A2 in causing Fuchs'
endothelial corneal dystrophy (FECD) is not controversial and has been confirmed by …

Mutations in the solute linked carrier family 4 member 11 (SLC4A11) gene are associated
with congenital hereditary endothelial dystrophy (CHED) and Fuchs corneal endothelial …

The cornea, the eye's outermost layer, protects the eye from the environment. The cornea's
innermost layer is an endothelium separating the stromal layer from the aqueous humor. A …

Harboyan syndrome or corneal dystrophy and progressive deafness (MIM# 217400) is
characterized by congenital hereditary endothelial dystrophy (CHED) and progressive …