Regulatory T cells (Tregs), possess a pivotal function in the maintenance of immune
homeostasis. The dysregulated activity of Tregs has been associated with the onset of …

Eicosanoids comprise a group of oxidation products of arachidonic and 5, 8, 11, 14, 17-
eicosapentaenoic acids formed by oxygenases and downstream enzymes. The two major …

Women have higher prevalence of asthma compared with men. In asthma, allergic airway
inflammation is initiated by IL-33 signaling through ST2, leading to increased IL-4, IL-5, and …

COPD poses a significant global public health challenge, primarily characterised by
irreversible airflow restriction and persistent respiratory symptoms. The hallmark pathology …

The development of graft versus host disease (GVHD) represents a long-standing
complication of allogeneic hematopoietic cell transplantation (allo-HCT). Different …

Methods Subjects initiating PGI 2 analog therapy for PAH for clinical indications were invited
to participate in a research study (Vanderbilt University Medical Center Institutional Review …

Immunoregulation of inflammatory, infection‐triggered processes in the brain constitutes a
central mechanism to control devastating disease manifestations such as epilepsy …

Prostacyclin is a metabolic product of the cyclooxygenase pathway that is constitutively
expressed and can be induced during inflammatory conditions. While prostacyclin and its …

Prostaglandins (PGs) play a crucial and multifaceted role in various physiological processes
such as intercellular signaling, inflammation regulation, neurotransmission, vasodilation …

Background Severe bronchial asthma (BA) affects 5–10% of children, which imposes
socioeconomic burden. Therefore, it is crucial to identify biomarkers for risk stratification in …