The role of BDNF in peripheral nerve regeneration: activity-dependent treatments and Val66Met

CE McGregor, AW English - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Despite the ability of peripheral nerves to spontaneously regenerate after injury, recovery is
generally very poor. The neurotrophins have emerged as an important modulator of axon …

Critical Issues in BDNF Val66Met Genetic Studies of Neuropsychiatric Disorders

SJ Tsai - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Neurotrophins have been implicated in the pathophysiology of many neuropsychiatric
diseases. Brain-derived neurotrophic factor (BDNF) is the most abundant and widely …

Mechanisms controlling the expression and secretion of BDNF

JC Arévalo, R Deogracias - Biomolecules, 2023 - mdpi.com
Brain-derived nerve factor (BDNF), through TrkB receptor activation, is an important
modulator for many different physiological and pathological functions in the nervous system …

BDNF and pro-BDNF in serum and exosomes in major depression: Evolution after antidepressant treatment

T Gelle, RA Samey, B Plansont, B Bessette… - Progress in Neuro …, 2021 - Elsevier
Background The study of clinically related biological indicators in Major Depression (MD) is
important. The Brain Derived Neurotrophic Factor (BDNF) appears to play an important role …

New frontiers in neurodegeneration and regeneration associated with brain-derived neurotrophic factor and the rs6265 single nucleotide polymorphism

CA Szarowicz, K Steece-Collier… - International journal of …, 2022 - mdpi.com
Brain-derived neurotrophic factor is an extensively studied neurotrophin implicated in the
pathology of multiple neurodegenerative and psychiatric disorders including, but not limited …

Neurotrophin signalling in the human nervous system

S Ateaque, S Merkouris, YA Barde - Frontiers in molecular …, 2023 - frontiersin.org
This review focuses on neurotrophins and their tyrosine kinase receptors, with an emphasis
on their relevance to the function and dysfunction in the human nervous system. It also deals …

Impact of brain‐derived neurotrophic factor genetic polymorphism on cognition: A systematic review

YL Toh, T Ng, M Tan, A Tan, A Chan - Brain and behavior, 2018 - Wiley Online Library
Introduction Brain‐derived neurotrophic factor (BDNF) has an important role in the
neurogenesis and neuroplasticity of the brain. This systematic review was designed to …

[HTML][HTML] BDNF and cortisol integrative system–plasticity vs. degeneration: implications of the Val66Met polymorphism

GG de Assis, EV Gasanov - Frontiers in Neuroendocrinology, 2019 - Elsevier
BDNF is the neurotrophin mediating pro-neuronal survival and plasticity. Cortisol (COR), in
turn, is engaged in the coordination of several processes in the brain homeostasis. Stress …

Beyond good and evil: A putative continuum-sorting hypothesis for the functional role of proBDNF/BDNF-propeptide/mBDNF in antidepressant treatment

CRAF Diniz, PC Casarotto, L Resstel… - … & Biobehavioral Reviews, 2018 - Elsevier
Depression and posttraumatic stress disorder are assumed to be maladaptive responses to
stress and antidepressants are thought to counteract such responses by increasing BDNF …

BDNF pro-peptide: physiological mechanisms and implications for depression

M Kojima, K Matsui, T Mizui - Cell and tissue research, 2019 - Springer
Most growth factors are synthesized as precursors and biologically active forms are
generated by proteolytic cleavage of the pro-domain. However, the biological functions of …