Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of
differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under …

The constant changes in cancer cell bioenergetics are widely known as metabolic
reprogramming. Reprogramming is a process mediated by multiple factors, including …

Energy metabolism plays an important role in cell and tissue ability to effectively function,
maintain homeostasis, and perform repair. Yet, the role of energy metabolism in skeletal …

Oncogenic signaling pathway reprograms cancer cell metabolism to promote aerobic
glycolysis in favor of tumor growth. The ability of cancer cells to evade immunosurveillance …

Notch and Wnt signaling are highly conserved intercellular communication pathways
involved in developmental processes, such as hematopoiesis. Even though data from …

Background Combination therapy with BRAF and MEK inhibitors significantly improves
survival in BRAF mutated melanoma patients but is unable to prevent disease recurrence …

As a critical member of the ubiquitin-specific proteolytic enzyme family, ubiquitin-specific
peptidase 20 (USP20) regulates the stability of proteins via multiple signaling pathways. In …

Cellular senescence is a major hurdle for primary cell-based tissue engineering and
regenerative medicine. Telomere erosion, oxidative stress, the expression of oncogenes …

Stemness pertains to the intrinsic ability of mesenchymal stem cells (MSCs) to undergo self-
renewal and differentiate into multiple lineages, while simultaneously impeding their …

Human umbilical cord mesenchymal stem cells (hUCMSCs) exhibit potent self-renewal and
multilineage differentiation characteristics. They have garnered substantial attention within …