Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …

Danger signals are a hallmark of many common inflammatory diseases, and these stimuli
can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR …

A fundamental concept in immunology is that the innate immune system initiates or instructs
downstream adaptive immune responses. Inflammasomes are central players in innate …

Allergen immunotherapy is a cornerstone in the treatment of allergic children. The clinical
efficiency relies on a well‐defined immunologic mechanism promoting regulatory T cells and …

Nanovaccine-based immunotherapy has been considered as a major pillar to stimulate the
host immune system to recognize and eradicate tumor cells as well as establish a long-term …

The immune system plays a critical role in our health. No other component of human
physiology plays a decisive role in as diverse an array of maladies, from deadly diseases …

Vaccines containing novel adjuvant formulations are increasingly reaching advanced
development and licensing stages, providing new tools to fill previously unmet clinical …

Inflammasomes are a group of protein complexes built around several proteins, including
NLRP3, NLRC4, AIM2 and NLRP6. Recognition of a diverse range of microbial, stress and …

Adjuvants are used in many vaccines, but their mechanisms of action are not fully
understood. Studies from the past decade on adjuvant mechanisms are slowly revealing the …

Researchers working on the development of vaccines face an inherent dilemma: to
maximize immunogenicity without compromising safety and tolerability. Early vaccines often …