SOD1 and DJ‐1 converge at Nrf2 pathway: a clue for antioxidant therapeutic potential in neurodegeneration

P Milani, G Ambrosi, O Gammoh… - Oxidative medicine …, 2013 - Wiley Online Library
Neurodegenerative diseases share diverse pathological features and among these
oxidative stress (OS) plays a leading role. Impaired activity and reduced expression of …

MicroRNAs and long non-coding RNAs in genetic diseases

A Finotti, E Fabbri, I Lampronti, J Gasparello… - Molecular Diagnosis & …, 2019 - Springer
Since the discovery and classification of non-coding RNAs, their roles have gained great
attention. In this respect, microRNAs and long non-coding RNAs have been firmly …

ALS blood expression profiling identifies new biomarkers, patient subgroups, and evidence for neutrophilia and hypoxia

WR Swindell, CPS Kruse, EO List, DE Berryman… - Journal of translational …, 2019 - Springer
Background Amyotrophic lateral sclerosis (ALS) is a debilitating disease with few treatment
options. Progress towards new therapies requires validated disease biomarkers, but there is …

Long non-coding and coding RNAs characterization in peripheral blood mononuclear cells and spinal cord from amyotrophic lateral sclerosis patients

S Gagliardi, S Zucca, C Pandini, L Diamanti… - Scientific reports, 2018 - nature.com
Alteration in RNA metabolism, concerning both coding and long non-coding RNAs
(lncRNAs), may play an important role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis …

Altered TDP-43 structure and function: Key insights into aberrant RNA, mitochondrial, and cellular and systemic metabolism in amyotrophic lateral sclerosis

L Jiang, ST Ngo - Metabolites, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neuromuscular disorder with
no cure available and limited treatment options. ALS is a highly heterogeneous disease …

Biomarkers in human peripheral blood mononuclear cells: the state of the art in amyotrophic lateral sclerosis

O Pansarasa, M Garofalo, E Scarian, F Dragoni… - International journal of …, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease,
characterized by the progressive loss of lower motor neurons, weakness and muscle …

Characterization of SOD1-DT, a Divergent Long non-coding RNA in the locus of the SOD1 human gene

M Guerra, L Meola, S Lattante, A Conte, M Sabatelli… - Cells, 2023 - mdpi.com
Researchers studying Amyotrophic Lateral Sclerosis (ALS) have made significant efforts to
find a unique mechanism to explain the etiopathology of the different forms of the disease …

The expression discrepancy and characteristics of long non-coding RNAs in peripheral blood leukocytes from amyotrophic lateral sclerosis patients

Y Yu, D Pang, C Li, X Gu, Y Chen, R Ou, Q Wei… - Molecular …, 2022 - Springer
Amyotrophic lateral sclerosis (ALS) is known to be a progressive neurodegenerative
disease that affects upper and lower motor neurons. Less than 10% of ALS patients are …

Neuronal AChE splice variants and their non‐hydrolytic functions: redefining a target of AChE inhibitors?

M Zimmermann - British journal of pharmacology, 2013 - Wiley Online Library
AChE enzymatic inhibition is a core focus of pharmacological intervention in A lzheimer's
disease (AD). Yet, AChE has also been ascribed non‐hydrolytic functions, which seem …

[HTML][HTML] Long non coding RNAs and ALS: Still much to do

S Gagliardi, C Pandini, M Garofalo, M Bordoni… - Non-coding RNA …, 2018 - Elsevier
Alterations in RNA metabolism play an important role in Amyotrophic Lateral Sclerosis (ALS)
pathogenesis. The literature has described, so far, a small number of long non coding RNAs …