SOD1 and DJ‐1 converge at Nrf2 pathway: a clue for antioxidant therapeutic potential in neurodegeneration
Neurodegenerative diseases share diverse pathological features and among these
oxidative stress (OS) plays a leading role. Impaired activity and reduced expression of …
oxidative stress (OS) plays a leading role. Impaired activity and reduced expression of …
MicroRNAs and long non-coding RNAs in genetic diseases
Since the discovery and classification of non-coding RNAs, their roles have gained great
attention. In this respect, microRNAs and long non-coding RNAs have been firmly …
attention. In this respect, microRNAs and long non-coding RNAs have been firmly …
ALS blood expression profiling identifies new biomarkers, patient subgroups, and evidence for neutrophilia and hypoxia
Background Amyotrophic lateral sclerosis (ALS) is a debilitating disease with few treatment
options. Progress towards new therapies requires validated disease biomarkers, but there is …
options. Progress towards new therapies requires validated disease biomarkers, but there is …
Long non-coding and coding RNAs characterization in peripheral blood mononuclear cells and spinal cord from amyotrophic lateral sclerosis patients
S Gagliardi, S Zucca, C Pandini, L Diamanti… - Scientific reports, 2018 - nature.com
Alteration in RNA metabolism, concerning both coding and long non-coding RNAs
(lncRNAs), may play an important role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis …
(lncRNAs), may play an important role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis …
Altered TDP-43 structure and function: Key insights into aberrant RNA, mitochondrial, and cellular and systemic metabolism in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neuromuscular disorder with
no cure available and limited treatment options. ALS is a highly heterogeneous disease …
no cure available and limited treatment options. ALS is a highly heterogeneous disease …
Biomarkers in human peripheral blood mononuclear cells: the state of the art in amyotrophic lateral sclerosis
O Pansarasa, M Garofalo, E Scarian, F Dragoni… - International journal of …, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease,
characterized by the progressive loss of lower motor neurons, weakness and muscle …
characterized by the progressive loss of lower motor neurons, weakness and muscle …
Characterization of SOD1-DT, a Divergent Long non-coding RNA in the locus of the SOD1 human gene
M Guerra, L Meola, S Lattante, A Conte, M Sabatelli… - Cells, 2023 - mdpi.com
Researchers studying Amyotrophic Lateral Sclerosis (ALS) have made significant efforts to
find a unique mechanism to explain the etiopathology of the different forms of the disease …
find a unique mechanism to explain the etiopathology of the different forms of the disease …
The expression discrepancy and characteristics of long non-coding RNAs in peripheral blood leukocytes from amyotrophic lateral sclerosis patients
Y Yu, D Pang, C Li, X Gu, Y Chen, R Ou, Q Wei… - Molecular …, 2022 - Springer
Amyotrophic lateral sclerosis (ALS) is known to be a progressive neurodegenerative
disease that affects upper and lower motor neurons. Less than 10% of ALS patients are …
disease that affects upper and lower motor neurons. Less than 10% of ALS patients are …
Neuronal AChE splice variants and their non‐hydrolytic functions: redefining a target of AChE inhibitors?
M Zimmermann - British journal of pharmacology, 2013 - Wiley Online Library
AChE enzymatic inhibition is a core focus of pharmacological intervention in A lzheimer's
disease (AD). Yet, AChE has also been ascribed non‐hydrolytic functions, which seem …
disease (AD). Yet, AChE has also been ascribed non‐hydrolytic functions, which seem …
[HTML][HTML] Long non coding RNAs and ALS: Still much to do
S Gagliardi, C Pandini, M Garofalo, M Bordoni… - Non-coding RNA …, 2018 - Elsevier
Alterations in RNA metabolism play an important role in Amyotrophic Lateral Sclerosis (ALS)
pathogenesis. The literature has described, so far, a small number of long non coding RNAs …
pathogenesis. The literature has described, so far, a small number of long non coding RNAs …