The increasingly recognized role of different types of B cells and plasma cells in protective
and pathogenic immune responses combined with technological advances have generated …

The timely reconstitution and regain of function of a donor-derived immune system is of
utmost importance for the recovery and long-term survival of patients after allogeneic …

X-linked severe combined immunodeficiency (SCID-X1) is a profound deficiency of T, B, and
natural killer (NK) cell immunity caused by mutations in IL2RG encoding the common chain …

A relatively high number of different subsets of B‐cells are generated through the
differentiation of early B‐cell precursors into mature B‐lymphocytes in the bone marrow (BM) …

B cells develop from hematopoietic stem cells in the bone marrow. Once generated, they
serve multiple roles in immune regulation and host defense. However, their most important …

In humans, different B-cell subpopulations can be distinguished in peripheral bloodand
other tissues on the basis of differential expression of various surface markers. These …

Cytokines play critical roles in regulating the development, survival, differentiation, and
function of immune cells. Cytokines exert their function by binding specific receptor …

In this review we discuss the changes that occur in the B lymphocyte compartment of mice
and humans as they progress to old age, focusing on recent advances in this important area …

Gain-of-function (GOF) mutations in PIK3CD, encoding the p110δ subunit of
phosphatidylinositide 3-kinase (PI3K), cause a primary immunodeficiency. Affected …

Human immunodeficiency virus (HIV) disease is associated with dysregulation and
dysfunction involving all major lymphocyte populations, including B cells. Such perturbations …